tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate

Base Information

• Chemical Name: tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate
• CAS No.: 943321-52-6
• Molecular Formula: C₂₁H₂₂N₂O₄
• Molecular Weight: 366.417
• Mol file: 943321-52-6.mol

Synonyms:tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate

Chemical Property of tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate

There total 3 articles about tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

phthalimide (136918-14-4,85-41-6) + tert-butyl N-(2-hydroxy-2-phenylethyl)carbamate (67341-07-5) → tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate (943321-52-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 0.5h;

Reference yield:

2-Amino-1-phenylethanol (7568-93-6,1936-63-6) → tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate (943321-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: triphenylphosphine; diethylazodicarboxylate

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate (943321-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran

2: triphenylphosphine; diethylazodicarboxylate

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

upstream raw materials:

phthalimide

tert-butyl N-(2-hydroxy-2-phenylethyl)carbamate

di-tert-butyl dicarbonate

2-Amino-1-phenylethanol

Downstream raw materials:

2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [5-(2-amino-1-phenyl-ethylcarbamoyl)-2-chloro-phenyl]-amide

N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide 2,2,2-trifluoroacetate