N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Base Information

• Chemical Name: N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
• CAS No.: 1386979-97-0
• Molecular Formula: C₂₄H₂₁ClN₆O₃S
• Molecular Weight: 508.988
• Mol file: 1386979-97-0.mol

Synonyms:N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Chemical Property of N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide

There total 10 articles about N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(2-{4-chloro-3-[(2-methylsulfanyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-2-phenyl-ethyl)-carbamic acid tert-butyl ester (1386980-93-3) → N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide (1386979-97-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 12h;

Reference yield:

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde (770-31-0) → N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide (1386979-97-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 85 °C

1.2: 24 h / Heating

2.1: sodium hydroxide; water / methanol / 18 h / 65 °C

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 12 h / 65 °C

5.1: triethylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

With hydrogenchloride; water; potassium carbonate; triethylamine; HATU; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

(±)-tert-butyl N-(2-amino-2-phenylethyl)carbamate (174885-99-5) → N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide (1386979-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl N-(2-hydroxy-2-phenylethyl)carbamate

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

2-Amino-1-phenylethanol

tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate