diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate

Base Information

Chemical Name:diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate
CAS No.:1242272-97-4
Molecular Formula:C₁₇H₂₁BrFNO₄
Molecular Weight:0
Hs Code.:
Mol file:1242272-97-4.mol

Synonyms:diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate

Suppliers and Price of diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate

There total 2 articles about diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14160-68-0
4,4-diethoxy-heptanedioic acid 1,7-diethyl ester

: 65896-11-9
2-bromo-6-fluoroaniline

: 1242272-97-4
diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate

Guidance literature:: With acetic acid; at 145 ℃; Inert atmosphere;

Reference yield:

: 6317-49-3
4-oxopimelate

: 1242272-97-4
diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / ethanol / 18 h / Inert atmosphere; Reflux

2: acetic acid / 123 - 145 °C / Inert atmosphere

With toluene-4-sulfonic acid; acetic acid; In ethanol;
DOI:10.1021/acs.oprd.1c00128

Reference yield:

: 1242272-97-4
diethyl 4-[(2-bromo-6-fluorophenyl)imino]heptanedioate

: 1242273-06-8
(7R)-4-fluoro-7-[5-[(4-fluorophenyl)methyl]-1H-1,2,3-triazol-1-yl]-6,7,8,9-tetrahydro-pyrido[1,2-a]indole-10-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine / 16 h / 100 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 2 h / 66 °C / Inert atmosphere

2.2: 2.5 h / 60 °C / Inert atmosphere

3.1: bis(1,5-cyclooctadiene)diiridium(I) dichloride / toluene; N,N-dimethyl-formamide / 1.58 h / 100 °C / Inert atmosphere

4.1: CDX ketoreductase P₃H₂; NADP / aq. phosphate buffer; isopropyl alcohol / 20 h / 33 - 35 °C / pH 7.0 / Inert atmosphere; Enzymatic reaction

5.1: triethylamine; sodium azide / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere

6.1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / toluene / 13.25 h / 70 - 90 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium azide; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); N-Methyldicyclohexylamine; potassium tert-butylate; CDX ketoreductase P₃H₂; NADP; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; aq. phosphate buffer; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/acs.oprd.1c00128