Raloxifene N-Oxide

Base Information

• Chemical Name: Raloxifene N-Oxide
• CAS No.: 195454-31-0
• Molecular Formula: C₂₈H₂₇NO₅S
• Molecular Weight: 489.592
• Hs Code.: 2934990002
• Mol file: 195454-31-0.mol

Synonyms:Raloxifene N-Oxide;Raloxifene Related Compound C (20 mg) (1-(2-{4-[6-hydroxy-2-(4-hydroxyphenyl)benzothiophene-3-carbonyl]phenoxy}ethyl)piperidine 1-oxide);[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-oxido-1-piperidinyl)ethoxy]phenyl]Methanone;Raloxifene IMpurity: IMpurity B;Raloxifene EP IMpurity C;Raloxifene Related CoMpound C;1-(2-{4-[6-Hydroxy-2-(4-hydroxyphenyl)benzothiophene-3-carbonyl]phenoxy}ethyl)piperidine 1-oxide

Chemical Property of Raloxifene N-Oxide

Chemical Property:

• PSA: 124.43000
• LogP: 6.04660
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

Raloxifene N-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Raloxifene degradation material. Raloxifene N-Oxide (Raloxifene EP Impurity C) is a Raloxifene degradation material.

Technology Process of Raloxifene N-Oxide

There total 3 articles about Raloxifene N-Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

raloxifene hydrochloride (82640-04-8) → raloxifene N-oxide (195454-31-0)

Guidance literature:

raloxifene hydrochloride; With sodium hydroxide; In methanol; water;

With dihydrogen peroxide; In methanol; water; at 20 ℃; chemoselective reaction;

DOI:10.1016/j.xphs.2018.10.059

Reference yield:

H2O2was + aqueous H2O2was + Raloxifen (84449-90-1) → raloxifene N-oxide (195454-31-0)

Guidance literature:

In CHCl₃and; ethanol;

Reference yield:

aqueous H2 O2 + dihydrogen peroxide (7722-84-1) + Raloxifen (84449-90-1) → raloxifene N-oxide (195454-31-0)

Guidance literature:

In ethanol; chloroform;

upstream raw materials:

dihydrogen peroxide

Raloxifen

raloxifene hydrochloride

Refernces

• 1、 -. "Benzothiophenes, formulations containing same, and methods". . . Retrieved 2008/06/13.