(2-FLUORO-4-METHYL-PHENYL)-HYDRAZINE

Base Information

• Chemical Name: (2-FLUORO-4-METHYL-PHENYL)-HYDRAZINE
• CAS No.: 5596-75-8
• Molecular Formula: C7H9FN2
• Molecular Weight: 140.16
• Hs Code.: 2928000090
• Mol file: 5596-75-8.mol

Synonyms:(2-FLUORO-4-METHYL-PHENYL)-HYDRAZINE

Chemical Property of (2-FLUORO-4-METHYL-PHENYL)-HYDRAZINE

Chemical Property:

• Boiling Point: 213.2±28.0 °C(Predicted)
• PKA: 4.93±0.27(Predicted)
• PSA: 38.05000
• Density: 1.202±0.06 g/cm3(Predicted)
• LogP: 2.19300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

≥95% ^*data from raw suppliers

(2-Fluoro-4-methylphenyl)hydrazine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-FLUORO-4-METHYL-PHENYL)-HYDRAZINE

There total 1 articles about (2-FLUORO-4-METHYL-PHENYL)-HYDRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-fluoro-4-methylaniline (452-80-2) → (2-fluoro-4-methylphenyl)hydrazine (5596-75-8)

Guidance literature:

2-fluoro-4-methylaniline; With hydrogenchloride; sodium nitrite; In water; at -20 ℃; for 1h;

With tin(ll) chloride; In water; at -20 - 0 ℃; for 2h;

With sodium hydroxide; In water; pH=12;

Reference yield: 99.8%

2,6-dichloro-pyrimidine carbaldehyde (5305-40-8) + (2-fluoro-4-methylphenyl)hydrazine (5596-75-8) → 4,6-dichloro-5-{[(2-fluoro-4-methylphenyl)hydrazono]methyl}pyrimidine

Guidance literature:

With diethylamine; In 1,2-dimethoxyethane; at 20 ℃; for 3h;

Reference yield: 60.0%

acetylenedicarboxylic acid diethyl ester (762-21-0) + (2-fluoro-4-methylphenyl)hydrazine (5596-75-8) → ethyl 1-(2-fluoro-4-methylphenyl)-5-hydroxy-1H-pyrazole-3-carboxylate (1138036-79-9)

Guidance literature:

With potassium carbonate; In ethanol; for 18h; Heating / reflux;

upstream raw materials:

2-fluoro-4-methylaniline

Downstream raw materials:

ethyl 1-(2-fluoro-4-methylphenyl)-5-hydroxy-1H-pyrazole-3-carboxylate

Refernces

• 1、 -. "AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES". Page/Page column 102; 103. . Retrieved 2012/10/08.