2-Fluoro-4-methylaniline

Base Information

Chemical Name:2-Fluoro-4-methylaniline
CAS No.:452-80-2
Molecular Formula:C7H8FN
Molecular Weight:125.146
Hs Code.:29214300
NSC Number:147489
UNII:Z6EGC62G32
DSSTox Substance ID:DTXSID40196431
Nikkaji Number:J85.092F
Wikidata:Q72474351
Mol file:452-80-2.mol

Synonyms:2-fluoro-4-methylaniline

Suppliers and Price of 2-Fluoro-4-methylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Fluoro-4-methylaniline
5g
$ 60.00

TRC
2-Fluoro-4-methylaniline
10g
$ 75.00

TCI Chemical
2-Fluoro-4-methylaniline >97.0%(GC)(T)
25g
$ 274.00

TCI Chemical
2-Fluoro-4-methylaniline >97.0%(GC)(T)
5g
$ 94.00

SynQuest Laboratories
2-Fluoro-4-methylaniline 99%
1 g
$ 16.00

SynQuest Laboratories
2-Fluoro-4-methylaniline 99%
25 g
$ 23.00

SynQuest Laboratories
2-Fluoro-4-methylaniline 99%
100 g
$ 64.00

Sigma-Aldrich
2-Fluoro-4-methylaniline 99%
5g
$ 112.00

Sigma-Aldrich
2-Fluoro-4-methylaniline 99%
1g
$ 56.00

Oakwood
2-Fluoro-4-methylaniline 99%
5g
$ 12.00

Total 96 raw suppliers

Chemical Property of 2-Fluoro-4-methylaniline

Chemical Property:

Appearance/Colour:clear orange to orange-brown liquid
Vapor Pressure:0.239mmHg at 25°C
Melting Point:3 °C
Refractive Index:n20/D 1.533(lit.)
Boiling Point:196.5 °C at 760 mmHg
PKA:3?+-.0.10(Predicted)
Flash Point:79.4 °C
PSA：26.02000
Density:1.115 g/cm³
LogP:2.29750
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
Water Solubility.:Not miscible in water.
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:125.064077422
Heavy Atom Count:9
Complexity:94.9

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-4-methylaniline ^*data from reagent suppliers

Safty Information:

Pictogram(s): T, Xi
Hazard Codes:T,Xi
Statements: 23/24/25-36/37/38
Safety Statements: 26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)N)F
Uses 2-Fluoro-4-methylaniline is used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It is also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol. 2-Fluoro-4-methylaniline was used in the preparation of 6-chloro-5-fluoroindole via Leimgruber-Batcho reaction. It was also used in the preparation of an (S)-amino alcohol, 2-amino-3-(2-fluoro-4-methylphenyl)-propan-1-ol.

Technology Process of 2-Fluoro-4-methylaniline

There total 10 articles about 2-Fluoro-4-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 878285-13-3
3,5-difluoro-4-methylaniline

: 878285-14-4
2,5-difluoro-4-methylaniline

: 452-80-2
2-fluoro-4-methylaniline

: 452-77-7
3-fluoro-4-methyl-phenylamine

Guidance literature:: With trifluorormethanesulfonic acid; fluorine; at 20 ℃; Title compound not separated from byproducts;
DOI:10.1016/j.jfluchem.2005.02.013

Reference yield:

: 446-34-4
2-fluoro-4-methyl-1-nitrobenzene

: 452-80-2
2-fluoro-4-methylaniline

Guidance literature:: With hydrogenchloride; tin(ll) chloride;
DOI:10.1021/ja01510a021

Reference yield:

: 501-60-0,21650-54-4,30926-02-4
1,2-di(p-tolyl)diazene

: 452-80-2
2-fluoro-4-methylaniline

Guidance literature:: 1,2-di(p-tolyl)diazene; With silver nitrate; N-fluorobis(benzenesulfon)imide; palladium dichloride; In ethyl acetate; at 55 ℃; for 12h; Sealed tube;

With sodium tetrahydroborate; copper(l) chloride; In ethanol; at 20 ℃; for 0.166667h;