N3-PEG6-tBu

Base Information

• Chemical Name: N3-PEG6-tBu
• CAS No.: 406213-76-1
• Molecular Formula: C19H37N3O8
• Molecular Weight: 435.518
• Mol file: 406213-76-1.mol

Synonyms:N3-PEG6-tBu;N3-PEG6-CH2CH2COOtBu;21-Azido-4,7,10,13,16,19-hexaoxaheneicosanoic acid 1,1-dimethylethyl ester;Azido-PEG7-t-butly ester;N3-PEG6-CH2CH2COOtBu

Chemical Property of N3-PEG6-tBu

Chemical Property:

• PSA: 131.43000
• LogP: 1.58086
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

N3-PEG6-CH2CH2COOtBu min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG6-t-butyl ester is a PEG molecule consisting of an azide group and a t-butyl ester moiety. he azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The hydrophilic PEG5 spacer increases solubility in aqueous media.

Technology Process of N3-PEG6-tBu

There total 7 articles about N3-PEG6-tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.1%

tert-butyl 1-{[(4-methylphenyl)sulfonyl]oxy}-3,6,9,12,15,18-hexaoxahenicosan-21-oate (406213-75-0) → tert-butyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate (406213-76-1)

Guidance literature:

With sodium azide; sodium iodide; In water; acetone; Reflux;

Reference yield: 72.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol (86770-69-6) → tert-butyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate (406213-76-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/C8OB02097C

Reference yield:

C20H40O11S → tert-butyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate (406213-76-1)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1021/ja2083015

upstream raw materials:

tert-butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate

pentaethylene glycol

tert-Butyl acrylate

tert-butyl 1-{[(4-methylphenyl)sulfonyl]oxy}-3,6,9,12,15,18-hexaoxahenicosan-21-oate

Downstream raw materials:

tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate

C₂₅H₄₅N₃O₁₀S

C₃₁H₄₄F₅N₃O₁₀S

1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid