Hexaethylene glycol

Base Information

• Chemical Name: Hexaethylene glycol
• CAS No.: 2615-15-8
• Molecular Formula: C12H26O7
• Molecular Weight: 282.334
• Hs Code.: 2909499000
• European Community (EC) Number: 220-045-1
• NSC Number: 201209
• DSSTox Substance ID: DTXSID2058629
• Nikkaji Number: J49.380E
• Wikidata: Q27104720
• Metabolomics Workbench ID: 52524
• ChEMBL ID: CHEMBL1235082
• Mol file: 2615-15-8.mol

Synonyms:hexaethylene glycol

Chemical Property of Hexaethylene glycol

Chemical Property:

• Appearance/Colour: viscous colourless liquid
• Vapor Pressure: 0.000317mmHg at 25°C
• Melting Point: 5-7 ºC
• Refractive Index: n20/D 1.465(lit.)
• Boiling Point: 217 ºC (4 mmHg)
• PKA: 14.06±0.10(Predicted)
• Flash Point: 110 ºC
• PSA: 86.61000
• Density: 1.127
• LogP: -0.94600
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Miscible with chloroform and methanol.
• XLogP3: -1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 16
• Exact Mass: 282.16785316
• Heavy Atom Count: 19
• Complexity: 141

Purity/Quality:

99.3% ^*data from raw suppliers

Hexaethylene glycol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCOCCOCCOCCOCCO)O
• Description: Hexaethylene glycol is a polymer consisting of ethylene glycol monomers and two terminal hydroxyl groups. The PEG chain increases the water solubility of a compound in aqueous media. Increasing the number of ethylene glycol units within the entire chain improves the solubility properties of the PEG linker.
• Uses: Substrate employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH)-TMEDA.1 Hexaethylene Glycol is part of a leaf extract (Murdannia Bracteata) which exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fl uids. Hexaethylene glycol exhibits antioxidant, antimicrobial and anti-cancer properties. It also shows potential application as functional hydraulic fluids. It is used as a surfactant building block as well as used in biological sample preparation. Further, it is employed in the synthesis of binaphthol-based macrocyclic ethers using intramolecular oxidative coupling with CuCl(OH).

Technology Process of Hexaethylene glycol

There total 38 articles about Hexaethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,1,1,21,21,21-hexaphenyl-2,5,8,11,14,17,20-heptaoxaheneicosane (144270-96-2) → pentaethylene glycol (2615-15-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In dichloromethane; at 20 ℃; for 48h; under 38000 Torr;

DOI:10.1021/jo990620m

Reference yield: 98.0%

17-chloro-3,6,9,12,15-pentaoxaheptadecan-1-ol (28746-78-3) → pentaethylene glycol (2615-15-8)

Guidance literature:

With water; potassium carbonate; at 90 ℃; for 0.7h; Green chemistry;

DOI:10.1039/C9RA00590K

Reference yield: 98.0%

17-bromo-3,6,9,12,15-pentaoxaheptadecan-1-ol (136399-05-8) → pentaethylene glycol (2615-15-8)

Guidance literature:

With hexaethylene glycol bis(3-hexaethylene glycol imidazolium) dimesylate; potassium carbonate; In water; at 100 ℃; for 1h; chemoselective reaction; Green chemistry;

DOI:10.1021/acs.joc.5b00901

upstream raw materials:

ethylene glycol

ethylene dibromide

1,2-bis-tosyloxyethane

3-oxa-1,5-dichloropentane

Downstream raw materials:

19-(triphenylmethyl)-1,4,7,10,13,16,19-heptaoxanonadecanol

hexaethylene glycol monomethyl ether

Acrylic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester

17-<(4,4'-dimethoxytrityl)oxy>-3,6,9,12,15-pentaoxaheptadecan-1-ol

Refernces

• 1、 Cornforth,Morgan,Potts,Rees. "Preparation of antituberculous polyoxyethylene ethers of homogeneous structure". . p. 1659 - 1667. Retrieved 1973.
• 2、 Reddy, Mudumala Veeranarayana,Kang, Seok Min,Yoo, Suah,Woo, Sang Sik,Kim, Dong Wook. "Amino-polystyrene supported hexaethylene glycol-bridged ionic liquid as an efficient heterogeneous catalyst for water-mediated nucleophilic hydroxylation". . p. 9435 - 9442. Retrieved 2019/04/01.