rac 5-Desfluoro Voriconazole

Base Information

• Chemical Name: rac 5-Desfluoro Voriconazole
• CAS No.: 182369-73-9
• Molecular Formula: C₁₆H₁₅F₂N₅O
• Molecular Weight: 331.325
• Hs Code.: 2933998350
• Mol file: 182369-73-9.mol

Synonyms:rac 5-Desfluoro Voriconazole ;(+/-)-DesMonofluono Voriconazole;(R*,S*)-α-(2,4-Difluorophenyl)-β-Methyl-α-(1H-1,2,4-triazol-1-ylMethyl)-4-pyriMidineethanol;Voriconazole IMpurity B;(2RS,3SR)-2-(2,4-Difluorophenyl)-3-pyrimidin-4-yl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Chemical Property of rac 5-Desfluoro Voriconazole

Chemical Property:

• Boiling Point: 513.3±60.0 °C(Predicted)
• PKA: 11.76±0.29(Predicted)
• PSA: 76.72000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 2.03780

Purity/Quality:

99%, ^*data from raw suppliers

rac 5-Desfluoro Voriconazole| ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Voriconazole

Technology Process of rac 5-Desfluoro Voriconazole

There total 8 articles about rac 5-Desfluoro Voriconazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(4-chloropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (188416-44-6) → 2-(2,4-difluorophenyl)-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (182369-73-9)

Guidance literature:

With methanol; palladium on activated charcoal; ammonium formate; for 5h; Reflux;

Reference yield:

(2R,3R/2S,3S)-3-(4-chloropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol → (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (129793-37-9,182369-73-9)

Guidance literature:

With ammonium formate; palladium; In methanol; dichloromethane;

Reference yield:

1,2,4-Triazole (288-88-0) + (-)-(2R,3S)-2-(2,4-Difluorophenyl)-3-(pyrimidin-4-yl)butan-1,2-diol + methanesulfonyl chloride (124-63-0) → (2R,3S)-2-(2,4-difluorophenyl)-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (182369-73-9)

Guidance literature:

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

4-ethylpyrimidine

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

n-butyllithium

3-(4-chloropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 182369-73-9 rac 5-Desfluoro Voriconazole

Send

Send

Metric Ton KG G Pound L ML

Send

Send