4-Chloro-2-Methoxy-3-nitropyridine

Base Information

• Chemical Name: 4-Chloro-2-Methoxy-3-nitropyridine
• CAS No.: 934180-48-0
• Molecular Formula: C6H5ClN2O3
• Molecular Weight: 188.5685
• Hs Code.: 2933399990
• Mol file: 934180-48-0.mol

Synonyms:4-Chloro-2-Methoxy-3-nitropyridine

Chemical Property of 4-Chloro-2-Methoxy-3-nitropyridine

Chemical Property:

• Boiling Point: 276.0±35.0 °C(Predicted)
• PKA: 1.04±0.10(Predicted)
• PSA: 67.94000
• Density: 1.445±0.06 g/cm3(Predicted)
• LogP: 2.17500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2-methoxy-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-Methoxy-3-nitropyridine

There total 2 articles about 4-Chloro-2-Methoxy-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-hydroxy-3-nitro-4-chloropyridine (165547-79-5) + methyl iodide (74-88-4) → 4-chloro-2-methoxy-3-nitropyridine (934180-48-0)

Guidance literature:

With silver carbonate; In toluene; at 85 ℃; for 3.5h;

Reference yield: 55.0%

4-chloro-3-nitropyridin-2(1H)-one (165547-79-5) + methyl iodide (74-88-4) → 4-chloro-2-methoxy-3-nitropyridine (934180-48-0)

Guidance literature:

With silver carbonate; In benzene; at 50 ℃;

Reference yield: 76.0%

4-chloro-2-methoxy-3-nitropyridine (934180-48-0) → 4-chloro-2-methoxypyridin-3-amine (934180-49-1)

Guidance literature:

4-chloro-2-methoxy-3-nitropyridine; With water; tin(ll) chloride; In ethyl acetate; at 70 ℃; for 2h;

With sodium carbonate; In water; ethyl acetate; at 20 ℃; pH=9 - 10;

upstream raw materials:

2-hydroxy-3-nitro-4-chloropyridine

methyl iodide

4-chloro-3-nitropyridin-2(1H)-one

Downstream raw materials:

4-chloro-2-methoxypyridin-3-amine

C₁₃H₈ClN₃O₄

Refernces

• 1、 -. "Inhibitors of HIV-1 reverse transcriptase". Page/Page column 16. . Retrieved 2010/04/23.
• 2、 -. "9-Azabicyclo[3.3.1]nonane derivatives". Page/Page column 12/2. . Retrieved 2010/11/27.