Chemical Property of Pentoxifylline
Chemical Property:
- Appearance/Colour:White to off-white solid
- Melting Point:98-100°C
- Refractive Index:1.6000 (estimate)
- Boiling Point:531.3 °C at 760 mmHg
- PKA:0.50±0.70(Predicted)
- Flash Point:275.1 °C
- PSA：78.89000
- Density:1.31 g/cm3
- LogP:0.19300
- Storage Temp.:Store at RT
- Solubility.:H2O: ≥43 mg/mL
- XLogP3:0.3
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:5
- Exact Mass:278.13789045
- Heavy Atom Count:20
- Complexity:426
- Purity/Quality:
-
97%-103%, *data from raw suppliers
Pentoxifylline *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22
- Safety Statements:
36
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Drug Classes:Intermittent Claudication Agents
- Canonical SMILES:CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C
- Recent ClinicalTrials:RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine
- Recent EU Clinical Trials:Feasibility of Aggressive Albuminuria Reduction in Biopsy-Proven Diabetic Nephropathy - A Pilot Study
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Uses
Pentoxifylline is a methylxanthine phospho-diesterase inhibitor with favorable antiinflammatory effects and immunoregulatory properties.A metabolite of Pentifylline. Methylxanthine derivative that improves blood flow by decreasing blood viscosity. Phosphodiesterase inhibitor. Inhibits the synthesis of tumor necrosis factor a (TNF-a). Pentoxifylline can increase red blood cell deformability, reduce blood viscosity, and decrease platelet aggregation and thrombus formation. Pentoxifylline is an oral agent that improves perfusion of occluded vessels and is used to treat systemic vascular diseases. The retinal flow velocity in patients with RVO treated with pentoxifylline improved compared with placebo, but the study had a small number of patients (n = 8) and short follow-up (4 weeks), and no visual outcome data were reported. Pentoxifylline has been used:used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growthto intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour
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Indications
Pentoxifylline at a dose of 400 mg three times a day after meals was reported
to alleviate the symptoms in a small open trial.
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Therapeutic Function
Vasodilator
