(6-Ethoxy-4-methylpyridin-3-yl)boronic acid

Base Information

• Chemical Name: (6-Ethoxy-4-methylpyridin-3-yl)boronic acid
• CAS No.: 1256355-37-9
• Molecular Formula: C₈H₁₂BNO₃
• Molecular Weight: 180.999
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID00681858
• Wikidata: Q82606036
• Mol file: 1256355-37-9.mol

Synonyms:1256355-37-9;(6-Ethoxy-4-methylpyridin-3-yl)boronic acid;2-ETHOXY-4-METHYLPYRIDINE-5-BORONIC ACID;2-Ethoxy-4-methyl-5-pyridinylboronic acid;6-ETHOXY-4-METHYLPYRIDINE-3-BORONIC ACID;DTXSID00681858;MFCD07374995;AKOS006284111;AB40901;FD10250;BS-19850;(6-Ethoxy-4-methylpyridin-3-yl)boronicacid;CS-0174084;A890120

Chemical Property of (6-Ethoxy-4-methylpyridin-3-yl)boronic acid

Chemical Property:

• PSA: 62.58000
• LogP: -0.53150
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 181.0910234
• Heavy Atom Count: 13
• Complexity: 156

Purity/Quality:

98%min ^*data from raw suppliers

2-Ethoxy-4-methylpyridine-5-boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=CN=C(C=C1C)OCC)(O)O

Technology Process of (6-Ethoxy-4-methylpyridin-3-yl)boronic acid

There total 2 articles about (6-Ethoxy-4-methylpyridin-3-yl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

Trimethyl borate (121-43-7,63156-11-6) + 5-bromo-2-ethoxy-4-methylpyridine (610279-04-4) + water (7732-18-5) → (6-ethoxy-4-methylpyridin-3-yl)boronic acid (1256355-37-9)

Guidance literature:

5-bromo-2-ethoxy-4-methylpyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

Trimethyl borate; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

water; In tetrahydrofuran; hexane; at 23 ℃;

Reference yield:

5-bromo-2-chloro-4-methylpyridine (778611-64-6) → (6-ethoxy-4-methylpyridin-3-yl)boronic acid (1256355-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-methyl-pyrrolidin-2-one / 0.5 h / 150 °C / Microwave irradiation

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 2 h / -78 °C

2.3: 23 °C

With n-butyllithium; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane;

upstream raw materials:

5-bromo-2-chloro-4-methylpyridine

Trimethyl borate

5-bromo-2-ethoxy-4-methylpyridine

water

Refernces