6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one

Base Information

Chemical Name:6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one
CAS No.:1039456-85-3
Molecular Formula:C16H16ClFO2
Molecular Weight:294.7484432
Hs Code.:2914700090
DSSTox Substance ID:DTXSID80701205
Mol file:1039456-85-3.mol

Synonyms:1039456-85-3;6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one;6-chloro-9a-(2-fluoroethyl)-7-methoxy-2,9-dihydro-1H-fluoren-3-one;6-Chloro-9a-(2-fluoroethyl)-1,2,9,9a-tetrahydro-7-methoxy-3H-fluoren-3-one;6-chloro-9a-(2-fluoroethyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one;SCHEMBL1658799;DTXSID80701205;RYQILFWZLKOHDP-UHFFFAOYSA-N

Suppliers and Price of 6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one 95+%
1g
$ 772.00

American Custom Chemicals Corporation
6-CHLORO-9A-(2-FLUOROETHYL)-7-METHOXY-9,9A-DIHYDRO-1H-FLUOREN-3(2H)-ONE 95.00%
5MG
$ 495.51

Alichem
6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one
1g
$ 653.12

Total 6 raw suppliers

Chemical Property of 6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one

Chemical Property:

PSA：26.30000
Density:1.28
LogP:3.99700
Storage Temp.:2-8°C
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:294.0822856
Heavy Atom Count:20
Complexity:436

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)CC3(C2=CC(=O)CC3)CCF)Cl

Technology Process of 6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one

There total 3 articles about 6-Chloro-9a-(2-fluoroethyl)-7-methoxy-9,9a-dihydro-1H-fluoren-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-chloro-2-(2-fluoroethyl)-5-methoxy-2-(3-oxobutyl)-indan-1-one

: 1039456-85-3
6-chloro-9a-(2-fluoroethyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one

Guidance literature:: With pyrrolidine; acetic acid; In toluene; at 95 ℃; for 2h;

Reference yield:

: 4-chloro-2-(2-fluoro-ethyl)-5-methoxy-indan-1-one

: 1235963-09-3
6-chloro-2-(2-fluoroethyl)-5-methoxy-indan-1-one

: 78-94-4,25038-87-3
methyl vinyl ketone

: 886036-95-9
8-chloro-9a-(2-fluoroethyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one

: 1039456-85-3
6-chloro-9a-(2-fluoroethyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one

Guidance literature:: 4-chloro-2-(2-fluoro-ethyl)-5-methoxy-indan-1-one; 6-chloro-2-(2-fluoroethyl)-5-methoxy-indan-1-one; methyl vinyl ketone; With sodium methylate; In methanol; at 20 ℃; for 3h;

With pyrrolidine; acetic acid; In toluene; at 80 ℃; for 3.25h;

Reference yield:

: 1235963-09-3
6-chloro-2-(2-fluoroethyl)-5-methoxy-indan-1-one

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1039456-85-3
6-chloro-9a-(2-fluoroethyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one

Guidance literature:: 6-chloro-2-(2-fluoroethyl)-5-methoxy-indan-1-one; methyl vinyl ketone; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 55 ℃; for 24h; Inert atmosphere;

With pyrrolidine; acetic acid; In toluene; at 90 ℃; for 15h; Inert atmosphere;
DOI:10.1021/ol800971f