(1R)-2α-Phenylcyclopropane-1β-carboxylic acid

Base Information

• Chemical Name: (1R)-2α-Phenylcyclopropane-1β-carboxylic acid
• CAS No.: 3471-10-1
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Mol file: 3471-10-1.mol

Synonyms:(1R)-2α-Phenylcyclopropane-1β-carboxylic acid;(1R,2R)-2-Phenylcyclopropanecarboxylic acid

Chemical Property of (1R)-2α-Phenylcyclopropane-1β-carboxylic acid

Chemical Property:

• Melting Point: 92 °C
• Boiling Point: 317.1±31.0 °C(Predicted)
• PKA: 4.57±0.10(Predicted)
• PSA: 37.30000
• Density: 1.250±0.06 g/cm3(Predicted)
• LogP: 1.87470
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

(1R,2R)-2-Phenylcyclopropanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R)-2α-Phenylcyclopropane-1β-carboxylic acid

There total 79 articles about (1R)-2α-Phenylcyclopropane-1β-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(-)-trans-2-phenylcyclopropanecarboxylic acid (2-hydroxy-1-phenylethyl)amide (928054-80-2) → (1R,2R)-trans-2-phenyl-1-cyclopropanecarboxylic acid (3471-10-1)

Guidance literature:

With sulfuric acid; water; In 1,4-dioxane; at 100 ℃; for 18h;

DOI:10.1002/cmdc.201600180

Reference yield: 96.0%

(1R,2R)-2-phenyl-cyclopropanecarboxylic acid ethyl ester (97-71-2,946-38-3,946-39-4,34702-96-0,34702-97-1,34703-00-9,34716-60-4,63038-62-0,63038-63-1) → (1R,2R)-trans-2-phenyl-1-cyclopropanecarboxylic acid (3471-10-1)

Guidance literature:

With sodium hydroxide; for 5h; Heating;

DOI:10.1016/S0957-4166(96)00457-0

Reference yield: 91.0%

cis-1-ethoxycarbonyl-2-phenylcyclopropane (946-38-3) → (1S*,2R*)-2-phenylcyclopropane-1-carboxylic acid (939-89-9,939-90-2,3471-10-1,5685-38-1,23020-15-7,23020-18-0,42916-14-3,48126-51-8,67528-68-1,111956-00-4,111956-01-5)

Guidance literature:

With ethanol; potassium hydroxide; at 20 ℃;

DOI:10.1021/ja101557k

upstream raw materials:

(1R,2R)-2-phenyl-cyclopropanecarboxylic acid ethyl ester

trans-2- phenylcyclopropane-1-carbaldehyde

(2R,4S)-(+)-5,5-dimethyl-4-phenyl-2-(trans-2-phenylcyclopropyl)-1,3-dioxane

(R,R)-trans-2-phenyl-cyclopropane-1-carboxylic acid benzyl ester

Downstream raw materials:

(-)-(1R,2S)-trans (2-phenyl-cyclopropyl)carbaminic acid tert-butyl ester

(1R,2R)-2-phenylcyclopropanecarboxylic acid methyl ester

[4-(2,4-Dimethyl-phenyl)-piperazin-1-yl]-((1R,2R)-2-phenyl-cyclopropyl)-methanone

[4-(2,4-Dichloro-phenyl)-piperazin-1-yl]-((1R,2R)-2-phenyl-cyclopropyl)-methanone