((1S,5R)-5-(3-methoxyphenyl)-2-azabicyclo[3.3.1]nonan-2-yl)-((1'R,2'R)-2-phenylcyclopropyl)methanone

Base Information

Chemical Name:((1S,5R)-5-(3-methoxyphenyl)-2-azabicyclo[3.3.1]nonan-2-yl)-((1'R,2'R)-2-phenylcyclopropyl)methanone
CAS No.:1265913-01-6
Molecular Formula:C₂₅H₂₉NO₂
Molecular Weight:375.511
Hs Code.:

Synonyms:((1S,5R)-5-(3-methoxyphenyl)-2-azabicyclo[3.3.1]nonan-2-yl)-((1'R,2'R)-2-phenylcyclopropyl)methanone

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Chemical Property of ((1S,5R)-5-(3-methoxyphenyl)-2-azabicyclo[3.3.1]nonan-2-yl)-((1'R,2'R)-2-phenylcyclopropyl)methanone

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Technology Process of ((1S,5R)-5-(3-methoxyphenyl)-2-azabicyclo[3.3.1]nonan-2-yl)-((1'R,2'R)-2-phenylcyclopropyl)methanone

There total 5 articles about ((1S,5R)-5-(3-methoxyphenyl)-2-azabicyclo[3.3.1]nonan-2-yl)-((1'R,2'R)-2-phenylcyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 938462-79-4
1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

: 3471-10-1
(1R,2R)-trans-2-phenyl-1-cyclopropanecarboxylic acid

: 1265913-01-6
((1S,5R)-5-(3-methoxyphenyl)-2-azabicyclo[3.3.1]nonan-2-yl)-((1'R,2'R)-2-phenylcyclopropyl)methanone

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm1011676

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 1265913-01-6
((1S,5R)-5-(3-methoxyphenyl)-2-azabicyclo[3.3.1]nonan-2-yl)-((1'R,2'R)-2-phenylcyclopropyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 20 h / 20 °C

2.1: potassium cyanide; cobalt(II) chloride hexahydrate; nickel(II) cyanide tetrahydrate; hydrogen; potassium hydroxide / toluene / 2 h / 95 °C

2.2: 48 h / 95 °C

3.1: methanol / Heating

4.1: sodium hydrogencarbonate / water

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With potassium cyanide; nickel(II) cyanide tetrahydrate; cobalt(II) chloride hexahydrate; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; water; toluene;
DOI:10.1021/jm1011676

Reference yield:

: 263893-73-8
((1R,4aS)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methanaminium (1R,2R)-2-phenylcyclopropane-1-carboxylate

: 1265913-01-6
((1S,5R)-5-(3-methoxyphenyl)-2-azabicyclo[3.3.1]nonan-2-yl)-((1'R,2'R)-2-phenylcyclopropyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;
DOI:10.1021/jm1011676