2-(4-broMophenyl)cyclopropanaMine

Base Information

• Chemical Name: 2-(4-broMophenyl)cyclopropanaMine
• CAS No.: 90561-75-4
• Molecular Formula: C₉H₁₀BrN
• Molecular Weight: 212.089
• Hs Code.: 2921499090
• Mol file: 90561-75-4.mol

Synonyms:2-(4-broMophenyl)cyclopropanaMine;2-(4-Bromo-phenyl)-cyclopropylamine

Chemical Property of 2-(4-broMophenyl)cyclopropanaMine

Chemical Property:

• Boiling Point: 271.1±40.0 °C(Predicted)
• PKA: 8.14±0.10(Predicted)
• PSA: 26.02000
• Density: 1.502±0.06 g/cm3(Predicted)
• LogP: 2.96400

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Bromophenyl)cyclopropanamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-broMophenyl)cyclopropanaMine

There total 5 articles about 2-(4-broMophenyl)cyclopropanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1-(4-Bromo-phenyl)-pent-1-en-3-one (65591-79-9) → (1S,2R)-(+)-2-(4-bromophenyl)cyclopropyl-1-amine (90561-75-4)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium tert-butylate / dimethyl sulfoxide

2: potassium carbonate / methanol / Reflux

3: diphenylphosphoranyl azide; triethylamine / toluene / Reflux

4: hydrogenchloride / methanol

With hydrogenchloride; diphenylphosphoranyl azide; potassium tert-butylate; potassium carbonate; triethylamine; In methanol; dimethyl sulfoxide; toluene;

DOI:10.1371/journal.pone.0170301

Reference yield:

trans-(1S,2S)/(1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylic acid (6142-65-0,31501-85-6,77255-26-6,2137065-16-6) → (1S,2R)-(+)-2-(4-bromophenyl)cyclopropyl-1-amine (90561-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenylphosphoranyl azide; triethylamine / toluene / Reflux

2: hydrogenchloride / methanol

With hydrogenchloride; diphenylphosphoranyl azide; triethylamine; In methanol; toluene;

DOI:10.1371/journal.pone.0170301

Reference yield:

(±)-trans-O-tert-butyl-N-(2-(4-bromophenyl)cyclopropyl)carbamate (1418287-95-2) → (1S,2R)-(+)-2-(4-bromophenyl)cyclopropyl-1-amine (90561-75-4)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1371/journal.pone.0170301

upstream raw materials:

(E)-1-(4-Bromo-phenyl)-pent-1-en-3-one

trans-(1S,2S)/(1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylic acid

(±)-trans-O-tert-butyl-N-(2-(4-bromophenyl)cyclopropyl)carbamate

ethyl trans-2-(p-bromophenyl)-1-cyclopropanecarboxylate