SAR-260301

Base Information

• Chemical Name: SAR-260301
• CAS No.: 1260612-13-2
• Molecular Formula: C19H22N4O3
• Molecular Weight: 354.40298
• Mol file: 1260612-13-2.mol

Synonyms:SAR-260301;(S)-2-(2-(2-Methylindolin-1-yl)-2-oxoethyl)-6-MorpholinopyriMidin-4(3H)-one

Chemical Property of SAR-260301

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SAR-260301

There total 4 articles about SAR-260301 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (1260544-00-0) + (S)-(-)-2-methylindoline (22160-09-4) → 2-{2-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one (1260612-13-2)

Guidance literature:

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1039/d0sc05884j

Reference yield:

2-{2-[2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one → 2-{2-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one (1260612-13-2) + 2-{2-[(2R)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one

Guidance literature:

With Chiralpak T₃₀₄ 20; Resolution of racemate;

Reference yield:

N-benzyl-2-(2-propenyl)aniline (150596-82-0) → 2-{2-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one (1260612-13-2)

Guidance literature:

Multi-step reaction with 3 steps

1: C₆₇H₇₈IrN₂⁽¹⁺⁾*F₆P^(1-) / tetrahydrofuran / 20 °C

2: palladium on activated charcoal; ammonium formate / methanol

3: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

With pyridine; palladium on activated charcoal; ammonium formate; C₆₇H₇₈IrN₂⁽¹⁺⁾*F₆P^(1-); 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1039/d0sc05884j

upstream raw materials:

ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate

N-benzyl-2-(2-propenyl)aniline

sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate

(S)-(-)-2-methylindoline