ethyl 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate

Base Information

• Chemical Name: ethyl 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate
• CAS No.: 1260543-99-4
• Molecular Formula: C12H17N3O4
• Molecular Weight: 267.28
• Mol file: 1260543-99-4.mol

Synonyms:ethyl 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate;Ethyl 2-(4-morpholino-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

Chemical Property of ethyl 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate

Chemical Property:

• PSA: 84.52000
• LogP: -0.22290

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate ^*data from reagent suppliers

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate

There total 2 articles about ethyl 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

morpholine (110-91-8,99108-56-2) + ethyl 3-ethoxy-3-iminopropanoate hydrochloride (2318-25-4,165895-16-9) → ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (1260543-99-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 95 ℃; for 30h;

DOI:10.1021/jm300241b

Reference yield:

morpholine (110-91-8,99108-56-2) + ethyl β-amino-β-ethoxyacrylate hydrochloride (34570-16-6) → ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (1260543-99-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; Reflux;

DOI:10.1021/jm401642q

Reference yield: 58.0%

ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (1260543-99-4) + 4-phenyl-2,3-dihydro-1H-indole (179473-53-1) → 6-(morpholin-4-yl)-2-[2-oxo-2-(4-phenyl-2,3-dihydro-1H-indol-1-yl)ethyl]pyrimidin-4(3H)-one (1383973-89-4)

Guidance literature:

ethyl [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 48h;

4-phenyl-2,3-dihydro-1H-indole; With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jm401642q

upstream raw materials:

morpholine

ethyl 3-ethoxy-3-iminopropanoate hydrochloride

ethyl β-amino-β-ethoxyacrylate hydrochloride

Downstream raw materials:

N-(4-fluoro-2-hydroxyphenyl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide

C₁₇H₂₀N₄O₄

2-[(1-methyl-4-phenyl-1H-benzimidazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one

2-[(1-methyl-7-phenyl-1H-benzimidazol-2-yl)methyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one

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