6-MALEIMIDO-1-HEXANAL

Base Information

• Chemical Name: 6-MALEIMIDO-1-HEXANAL
• CAS No.: 1076198-37-2
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.21512
• Mol file: 1076198-37-2.mol

Synonyms:6-MALEIMIDO-1-HEXANAL

Chemical Property of 6-MALEIMIDO-1-HEXANAL

Chemical Property:

• PSA: 54.45000
• LogP: 0.60860
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

6-Maleimido-1-hexanal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The alcohol is M138560

Technology Process of 6-MALEIMIDO-1-HEXANAL

There total 2 articles about 6-MALEIMIDO-1-HEXANAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1-(6-hydroxyhexyl)-1 H-pyrrole- 2,5-dione (157503-18-9) → 6-(2,5-dioxo-2,5-dihydro-1 H-pyrrol-1-yl)hexanal (1076198-37-2)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; for 2h;

Reference yield:

6-amino-1-hexanol (4048-33-3) → 6-(2,5-dioxo-2,5-dihydro-1 H-pyrrol-1-yl)hexanal (1076198-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methyl chloroformate; 4-methyl-morpholine / ethyl acetate / 0.5 h / 0 °C

1.2: 0.5 h

2.1: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 2 h

With 4-methyl-morpholine; sodium hydrogencarbonate; Dess-Martin periodane; methyl chloroformate; In dichloromethane; ethyl acetate;

Reference yield:

6-(2,5-dioxo-2,5-dihydro-1 H-pyrrol-1-yl)hexanal (1076198-37-2) → ethyl (2S,4R)-4-(2-((1R,3R)-1-acetoxy-3-((2S,3S)-2-((R)-1-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl)piperidine-2-carboxamido)-N,3-dimethylpentanamido)-4-methylpentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

2.1: HATU; N-ethyl-N,N-diisopropylamine; acetic anhydride / N,N-dimethyl-formamide / 0.25 h

2.2: 0.5 h

3.1: pyridine / 2 h

With pyridine; acetic anhydride; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; HATU; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

upstream raw materials:

6-amino-1-hexanol

1-(6-hydroxyhexyl)-1 H-pyrrole- 2,5-dione