Bicyclo[2.2.2]octane-1,4-diol

Base Information

• Chemical Name: Bicyclo[2.2.2]octane-1,4-diol
• CAS No.: 1194-44-1
• Molecular Formula: C8H14O2
• Molecular Weight: 142.198
• Hs Code.: 2906199090
• Mol file: 1194-44-1.mol

Synonyms:Bicyclo[2.2.2]octane-1,4-diol

Chemical Property of Bicyclo[2.2.2]octane-1,4-diol

Chemical Property:

• Melting Point: 282-283 °C(Solv: xylene (1330-20-7))
• Boiling Point: 246.1±8.0 °C(Predicted)
• PKA: 14?+-.0.40(Predicted)
• PSA: 40.46000
• Density: 1.335±0.06 g/cm3(Predicted)
• LogP: 0.81640

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bicyclo[2.2.2]octane-1,4-diol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bicyclo[2.2.2]octane-1,4-diol

There total 24 articles about Bicyclo[2.2.2]octane-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

1,4-dimethylidenecyclohexane (4982-20-1) → 1,4-dihydroxybicyclo[2.2.2]octane (1194-44-1)

Guidance literature:

1,4-dimethylidenecyclohexane; With [bis(acetoxy)iodo]benzene; palladium diacetate; acetic acid; In dimethyl sulfoxide; at 20 ℃;

With sulfuric acid; In butan-1-ol; at 80 ℃; for 3h;

Reference yield: 70.0%

1,4-Diacetoxybicyclo<2.2.2>octane (10364-35-9) → 1,4-dihydroxybicyclo[2.2.2]octane (1194-44-1)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Heating;

Reference yield: 42.0%

1,4-Diethoxy-bicyclo[2.2.2]octane (78070-46-9) → 1,4-dihydroxybicyclo[2.2.2]octane (1194-44-1)

Guidance literature:

With pyridine hydrochloride; at 200 - 210 ℃; for 7h;

upstream raw materials:

1,4-Dichloro-bicyclo<2.2.2>octane

bicyclo[2.2.2]octane-1,4-dibromide

1,4-Diacetoxybicyclo<2.2.2>octane

1,4-Diethoxy-bicyclo[2.2.2]octane

Downstream raw materials:

1,4-Bicyclo<2,2,2>oktylen-di-p-hexoxybenzoat

1,4-Bicyclo<2,2,2>oktylen-di-p-oktoxy-benzoat

1,4-Bicyclo<2,2,2>oktylen-di-p-aethoxybenzoat

1,4-Bicyclo<2,2,2>oktylen-di-p-propoxybenzoat

Refernces

• 1、 -. "PROCESS FOR PREPARING BICYCLO[2.2.2]OCTANE-1,4-DIOL". Paragraph 00020. . Retrieved 2021/05/15.
• 2、 -. "SYNTHESIS OF BICYCLO(2.2.2)OCTANES". Paragraph 0054. . Retrieved 2018/05/15.