AZD5423

Base Information

• Chemical Name: AZD5423
• CAS No.: 1034148-04-3
• Molecular Formula: C25H21F4N3O3
• Molecular Weight: 487.454
• Mol file: 1034148-04-3.mol

Synonyms:AZD5423

Chemical Property of AZD5423

Chemical Property:

• PSA: 65.38000
• LogP: 5.75120

Purity/Quality:

>98 % ^*data from raw suppliers

AZD5423 99.85% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AZD5423

There total 5 articles about AZD5423 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ 2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-yl)acetamide (1034148-04-3)

Guidance literature:

Reference yield: 52.0%

(1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-amine (1034153-23-5) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-yl)acetamide (1034148-04-3)

Guidance literature:

With triethylamine;

DOI:10.1021/acs.jmedchem.7b01215

Reference yield:

(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-amine hydrochloride (1417334-58-7) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-yl)acetamide (1034148-04-3)

Guidance literature:

With triethylamine; In tert-butyl methyl ether; at 20 - 40 ℃; for 0.75h; Industrial scale;

upstream raw materials:

(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-amine hydrochloride

trifluoroacetic anhydride

ethyl trifluoroacetate,

(1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-amine

Downstream raw materials:

2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide

Refernces

• 1、 Hemmerling, Martin,Nilsson, Stinabritt,Edman, Karl,Eirefelt, Stefan,Russell, Wayne,Hendrickx, Ramon,Johnsson, Eskil,K?rrman M?rdh, Carina,Berger, Markus,Rehwinkel, Hartmut,Abrahamsson, Anna,Dahmén, Jan,Eriksson, Anders R.,Gabos, Balint,Henriksson, Krister,Hossain, Nafizal,Ivanova, Svetlana,Jansson, Anne-Helene,Jensen, Tina J.,Jerre, Anders,Johansson, Henrik,Klingstedt, Tomas,Lepist?, Matti,Lindsj?, Martin,Mile, Irene,Nikitidis, Grigorios,Steele, John,Tehler, Ulrika,Wissler, Lisa,Hansson, Thomas. "Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases". . p. 8591 - 8605. Retrieved 2017/11/03.
• 2、 -. "INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS". Example 6. . Retrieved 2008/12/06.