2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide

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Chemical Name:2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide
CAS No.:1034148-48-5
Molecular Formula:C₂₄H₁₉F₄N₃O₃
Molecular Weight:473.427
Hs Code.:

Synonyms:2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide

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Chemical Property of 2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide

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Technology Process of 2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide

There total 2 articles about 2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1034148-04-3
2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-yl)acetamide

: 1034148-48-5
2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide

Guidance literature:: With aluminum (III) chloride; 1-dodecylthiol; In toluene; at 40 ℃; for 1h;

Reference yield:

: ammonium 3-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-2-(2,2,2-trifluoroacetamido)propyl)phenyl sulfate

: 1034148-48-5
2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide

Guidance literature:: In [⁽²⁾H₆]acetone;
DOI:10.1021/acs.jmedchem.7b01215

Reference yield: 37.0%

: 1034148-48-5
2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide

: ammonium 3-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-2-(2,2,2-trifluoroacetamido)propyl)phenyl sulfate

Guidance literature:: 2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-hydroxyphenyl)propan-2-yl)acetamide; With sulfur trioxide pyridine complex; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With ammonium hydroxide; In acetonitrile;
DOI:10.1021/acs.jmedchem.7b01215