BenzenaMine, 2-broMo-5-iodo-

Base Information

• Chemical Name: BenzenaMine, 2-broMo-5-iodo-
• CAS No.: 111721-74-5
• Molecular Formula: C6H5BrIN
• Molecular Weight: 297.921
• Hs Code.: 2921420090
• Mol file: 111721-74-5.mol

Synonyms:BenzenaMine, 2-broMo-5-iodo-;2-Bromo-5-iodoaniline;1-Amino-2-bromo-5-iodobenzene;2-Amino-1-bromo-4-iodobenzene;2-bromo-5-iodoBenzenamine;2-Bromo-5-iodoaniline96%;2-Bromo-5-iodo-phenylamine

Chemical Property of BenzenaMine, 2-broMo-5-iodo-

Chemical Property:

• Melting Point: 70-75°C
• Boiling Point: 315.1±27.0 °C(Predicted)
• PKA: 1.57±0.10(Predicted)
• PSA: 26.02000
• Density: 2.292±0.06 g/cm3(Predicted)
• LogP: 3.21710

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-iodoaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BenzenaMine, 2-broMo-5-iodo-

There total 4 articles about BenzenaMine, 2-broMo-5-iodo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.8%

2-bromo-5-iodonitrobenzene (713512-18-6) → 2-bromo-5-iodoaniline (111721-74-5)

Guidance literature:

With iron; ammonium chloride; In water; at 85 - 95 ℃;

Reference yield: 41.0%

3-Iodoaniline (626-01-7) → 2-bromo-5-iodoaniline (111721-74-5)

Guidance literature:

With N-Bromosuccinimide; In benzene; at 23 ℃; for 20h;

DOI:10.1021/ja907193b

Reference yield:

4-iodo-2-nitroaniline (20691-72-9) → 2-bromo-5-iodoaniline (111721-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; sodium nitrite / water / 15 °C

1.2: 40 °C

2.1: iron; ammonium chloride / water / 85 - 95 °C

With sulfuric acid; iron; ammonium chloride; sodium nitrite; In water;

upstream raw materials:

3-Iodoaniline

2-nitro-aniline

4-iodo-2-nitroaniline

2-bromo-5-iodonitrobenzene

Downstream raw materials:

(R)-tert-butyl 1-(3'-amino-4'-bromo-5,6-dimethoxybiphenyl-3-yl)-2-(benzyloxy)ethylcarbamate

2-bromo-5-iodophenol

Refernces

• 1、 Garfunkle, Joie,Kimball, F. Scott,Trzupek, John D.,Takizawa, Shinobu,Shimamura, Hiroyuki,Tomishima, Masaki,Boger, Dale L.. "Total synthesis of chloropeptin II (complestatin) and chloropeptin I". supporting information; experimental part. p. 16036 - 16038. Retrieved 2010/02/15.