2-Bromo-5-iodophenol

Base Information

• Chemical Name: 2-Bromo-5-iodophenol
• CAS No.: 932372-99-1
• Molecular Formula: C6H4BrIO
• Molecular Weight: 298.906
• Hs Code.: 2908199090
• Mol file: 932372-99-1.mol

Synonyms:Phenol,2-bromo-5-iodo-;

Chemical Property of 2-Bromo-5-iodophenol

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.7
• Boiling Point: 285.054 °C at 760 mmHg
• PKA: 7.58±0.10(Predicted)
• Flash Point: 126.197 °C
• PSA: 20.23000
• Density: 2.37 g/cm³
• LogP: 2.75930
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-iodophenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-iodophenol

There total 5 articles about 2-Bromo-5-iodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-bromo-4-iodo-2-methoxybenzene (755027-18-0) → 2-bromo-5-iodophenol (932372-99-1)

Guidance literature:

With boron tribromide; In dichloromethane; at -10 - 0 ℃; for 17.5h;

Reference yield: 52.0%

2-bromo-5-iodoaniline (111721-74-5) → 2-bromo-5-iodophenol (932372-99-1)

Guidance literature:

2-bromo-5-iodoaniline; With sulfuric acid; sodium nitrite; In water; at 5 - 10 ℃;

With sulfuric acid; copper(II) sulfate; In water; at 80 ℃;

Reference yield:

4-iodo-2-nitroaniline (20691-72-9) → 2-bromo-5-iodophenol (932372-99-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid; sodium nitrite / water / 15 °C

1.2: 40 °C

2.1: iron; ammonium chloride / water / 85 - 95 °C

3.1: sulfuric acid; sodium nitrite / water / 5 - 10 °C

3.2: 80 °C

With sulfuric acid; iron; ammonium chloride; sodium nitrite; In water;

upstream raw materials:

1-bromo-4-iodo-2-methoxybenzene

2-nitro-aniline

4-iodo-2-nitroaniline

2-bromo-5-iodoaniline

Downstream raw materials:

1-bromo-4-iodo-2-methoxybenzene

1-bromo-4-iodo-2-(methoxymethoxy)benzene

Refernces

• 1、 -. "HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE". Page/Page column 122-124. . Retrieved 2020/01/24.
• 2、 -. "Preparation method of 2-bromo-5-iodophenol". . . Retrieved 2019/03/08.