2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI

Base Information

• Chemical Name: 2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI
• CAS No.: 250714-79-5
• Molecular Formula: C11H14FNO4S
• Molecular Weight: 275.301
• Hs Code.: 2935009090
• Mol file: 250714-79-5.mol

Synonyms:2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI;N-(4-Fluorobenzenesulphonyl)valine;2-(4-Fluorobenzenesulphamido)-3-methylbutyricacid97%

Chemical Property of 2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI

Chemical Property:

• Melting Point: 159～161℃
• PSA: 91.85000
• LogP: 2.68490

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Fluorobenzenesulfamido)-3-methylbutyric acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI

There total 1 articles about 2-(4-FLUOROBENZENESULPHAMIDO)-3-METHYLBUTYRIC ACI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluorobenzenesulfonyl chloride (349-88-2) + D,L-valine (516-06-3,25609-85-2,7004-03-7,921-10-8) → N-((4-fluorophenyl)sulfonyl)valine (250714-79-5)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ol050869s

Reference yield: 71.0%

N-((4-fluorophenyl)sulfonyl)valine (250714-79-5) + para-xylene (106-42-3) → 1-fluoro-4-((4-methylbenzyl)sulfonyl)benzene (1494-30-0)

Guidance literature:

With sodium persulfate; silver fluoride; In water; acetonitrile; at 100 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1246/BCSJ.20200393

Reference yield: 58.0%

N-((4-fluorophenyl)sulfonyl)valine (250714-79-5) + methyl propargyl alcohol (764-01-2) → 2-[(4-but-2-ynyloxy-benzenesulfonyl)-methyl-amino]-3-methyl-butyric acid (287406-76-2)

Guidance literature:

methyl propargyl alcohol; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

N-((4-fluorophenyl)sulfonyl)valine; In DMF (N,N-dimethyl-formamide); for 24h; Heating / reflux;

With hydrogenchloride; In DMF (N,N-dimethyl-formamide); water; at 20 ℃;

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

D,L-valine

Downstream raw materials:

2-[(4-but-2-ynyloxy-benzenesulfonyl)-methyl-amino]-3-methyl-butyric acid

1-fluoro-4-((4-methylbenzyl)sulfonyl)benzene

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