N-(1-benzhydrylazetidin-3-yl)-N-(1,1-difluoro-2-hydroxyethyl)-2-Methylpropane-2-sulfinaMide

Base Information

Chemical Name:N-(1-benzhydrylazetidin-3-yl)-N-(1,1-difluoro-2-hydroxyethyl)-2-Methylpropane-2-sulfinaMide
CAS No.:1263296-87-2
Molecular Formula:C22H28F2N2O2S
Molecular Weight:422.539
Hs Code.:
Mol file:1263296-87-2.mol

Synonyms:N-(1-benzhydrylazetidin-3-yl)-N-(1,1-difluoro-2-hydroxyethyl)-2-Methylpropane-2-sulfinaMide

Suppliers and Price of N-(1-benzhydrylazetidin-3-yl)-N-(1,1-difluoro-2-hydroxyethyl)-2-Methylpropane-2-sulfinaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of N-(1-benzhydrylazetidin-3-yl)-N-(1,1-difluoro-2-hydroxyethyl)-2-Methylpropane-2-sulfinaMide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of N-(1-benzhydrylazetidin-3-yl)-N-(1,1-difluoro-2-hydroxyethyl)-2-Methylpropane-2-sulfinaMide

There total 3 articles about N-(1-benzhydrylazetidin-3-yl)-N-(1,1-difluoro-2-hydroxyethyl)-2-Methylpropane-2-sulfinaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1263296-86-1
ethyl 2-(1-benzhydryl-3-(1,1-dimethylethylsulfinamido)azetidin-3-yl)-2,2-difluoroacetate

: 1263296-87-2
N-(1-benzhydryl-3-(1,1-difluoro-2-hydroxyethyl)azetidin-3-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol103050c

Reference yield:

: N-(1-benzhydrylazetidin-3-ylidene)-2-methylpropane-2-sulfinamide

: 1263296-87-2
N-(1-benzhydryl-3-(1,1-difluoro-2-hydroxyethyl)azetidin-3-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) chloride; zinc / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

1.2: 5 h / 60 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; copper(l) chloride; zinc; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol103050c

Reference yield:

: 40320-60-3
N-benzhydryl 3-azetidinone

: 1263296-87-2
N-(1-benzhydryl-3-(1,1-difluoro-2-hydroxyethyl)azetidin-3-yl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 20 - 50 °C / Inert atmosphere

2.1: copper(l) chloride; zinc / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 5 h / 60 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

With titanium(IV) tetraethanolate; lithium aluminium tetrahydride; copper(l) chloride; zinc; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol103050c