6-benzhydryl-1-(tert-butylsulfinyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane

Base Information

Chemical Name:6-benzhydryl-1-(tert-butylsulfinyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane
CAS No.:1263296-75-8
Molecular Formula:C₂₂H₂₆F₂N₂OS
Molecular Weight:404.524
Hs Code.:

Synonyms:6-benzhydryl-1-(tert-butylsulfinyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane

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Chemical Property of 6-benzhydryl-1-(tert-butylsulfinyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane

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Technology Process of 6-benzhydryl-1-(tert-butylsulfinyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane

There total 4 articles about 6-benzhydryl-1-(tert-butylsulfinyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1263296-87-2
N-(1-benzhydryl-3-(1,1-difluoro-2-hydroxyethyl)azetidin-3-yl)-2-methylpropane-2-sulfinamide

: 1263296-75-8
6-benzhydryl-1-(tert-butylsulfinyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol103050c

Reference yield:

: N-(1-benzhydrylazetidin-3-ylidene)-2-methylpropane-2-sulfinamide

: 1263296-75-8
6-benzhydryl-1-(tert-butylsulfinyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) chloride; zinc / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

1.2: 5 h / 60 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; copper(l) chloride; zinc; In tetrahydrofuran; diethyl ether; 3.1: Mitsunobu reaction;
DOI:10.1021/ol103050c

Reference yield:

: 1263296-86-1
ethyl 2-(1-benzhydryl-3-(1,1-dimethylethylsulfinamido)azetidin-3-yl)-2,2-difluoroacetate

: 1263296-75-8
6-benzhydryl-1-(tert-butylsulfinyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; diethyl ether; 2: Mitsunobu reaction;
DOI:10.1021/ol103050c