N-Isopropyl-L-Proline

Base Information

• Chemical Name: N-Isopropyl-L-Proline
• CAS No.: 1141826-51-8
• Molecular Formula: C8H15NO2
• Molecular Weight: 171.239
• Mol file: 1141826-51-8.mol

Synonyms:(S)-1-Isopropyl-piperidine-2-carboxylic acid;2-Piperidinecarboxylic acid, 1-(1-methylethyl)-, (2S)-

Chemical Property of N-Isopropyl-L-Proline

Chemical Property:

• PSA: 40.54000
• LogP: 0.88170

Purity/Quality:

97% ^*data from raw suppliers

1-Isopropyl-L-pipecolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Isopropyl-L-Proline

There total 1 articles about N-Isopropyl-L-Proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetone (67-64-1) + pipecolinic acid (3105-95-1,83680-83-5) → (S)-1-isopropyl-piperidine-2-carboxylic acid (1141826-51-8,1218651-70-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 16h; under 760.051 Torr;

Reference yield:

(S)-1-isopropyl-piperidine-2-carboxylic acid (1141826-51-8,1218651-70-7) + (5R,8S)-7-[(S)-2-((S)-2-amino-2-cyclohexyl-acetylamino)-3,3-dimethyl-butyryl]-10,10-dimethyl-7-aza-dispiro[3.0.4.1]decane-8-carboxylic acid methylester (1247711-17-6) → (5R,8S)-7-((S)-2-{(S)-2-cyclohexyl-2-[((S)-1-isopropyl-piperidine-2-carbonyl)-amino]-acetylamino}3,3-dimethyl-butyryl)-10,10-dimethyl-7-aza-dispiro[3.0.4.1]decane-8-carboxylic acid methyl ester (1247711-19-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

(S)-1-isopropyl-piperidine-2-carboxylic acid (1141826-51-8,1218651-70-7) + C35H59N5O5*ClH (1141826-45-0) → C44H74N6O6 (1141826-55-2)

Guidance literature:

With 4-methyl-morpholine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

upstream raw materials:

acetone

pipecolinic acid

Downstream raw materials:

C₄₄H₇₄N₆O₆

(5R,8S)-7-((S)-2-{(S)-2-cyclohexyl-2-[((S)-1-isopropyl-piperidine-2-carbonyl)-amino]-acetylamino}3,3-dimethyl-butyryl)-10,10-dimethyl-7-aza-dispiro[3.0.4.1]decane-8-carboxylic acid methyl ester

(5R,8S)-7-((2S)-2-(((2S)-2-cyclohexyl-2-((((2S)-1-isopropylpiperidin-2-yl)carbonyl)amino)acetyl)amino)-3,3-dimethylbutanoyl)-10,10-dimethyl-N-((1R,2S)-1-(((1-propylcyclopropyl)sulfonyl)carbamoyl)-2-vinylcyclopropyl)-7-azadispiro[3.0.4.1]decane-8-carboxamide

(5R,8S)-7-((2S)-2-(((2S)-2-cyclohexyl-2-((((2S)-1-isopropylpiperidin-2-yl)carbonyl)amino)acetyl)amino)-3,3-dimethylbutanoyl)-10,10-dimethyl-N-((1R,2S)-1-(((1-propylcyclopropyl)sulfonyl)carbamoyl)-2-ethylcyclopropyl)-7-azadispiro[3.0.4.1]decane-8-carboxamide

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