cyclobutg

Base Information

• Chemical Name: cyclobutg
• CAS No.: 126062-18-8
• Molecular Formula: C₁₁H₁₅N₅O₃
• Molecular Weight: 265.272
• Mol file: 126062-18-8.mol

Synonyms:6H-Purin-6-one,2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-1,9-dihydro-, (1a,2b,3a)-(?à)-;6H-Purin-6-one,2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-1,9-dihydro-, (1a,2b,3a)-;Cyclobut G;SQ 33054;

Chemical Property of cyclobutg

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.882
• Boiling Point: 651.8°Cat760mmHg
• Flash Point: 348°C
• PSA: 130.05000
• Density: 1.92g/cm³
• LogP: -0.55520

Purity/Quality:

98%Min ^*data from raw suppliers

CYCLOBUT G 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cyclobutg

There total 10 articles about cyclobutg which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

6-chloro-9-purine (132332-77-5,137171-59-6) → 9-guanine (126062-18-8,126373-87-3,127759-89-1,129261-93-4,130464-69-6,130466-27-2,132077-79-3)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 3h; Ambient temperature;

DOI:10.1248/cpb.38.2719

Reference yield:

(1α,2β,3β)-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol, dibenzoate ester (126261-74-3,127759-91-5,132294-18-9,132294-26-9) → (+/-)-9-<(1β,2α,3β)-2,3-bis(hydroxymethyl)-1-cyclobutyl>guanine (126062-18-8,126373-87-3,127759-89-1,129261-93-4,130464-69-6,130466-27-2,132077-79-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / K₂CO₃ / 18-crown-6 / dimethylformamide / 16 h / 110 °C

2: 2.) aq. HCl / 1.) sodium methoxide / 1.) methanol, 40 deg C, 1.5 h.; 2.) methanol, 50 deg C, 6 h.

With hydrogenchloride; potassium carbonate; 18-crown-6 ether; sodium methylate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)88992-9

Reference yield:

C20H20O5 (126261-73-2,126373-88-4,127759-90-4,127759-93-7,132294-17-8,132294-25-8) → (+/-)-9-<(1β,2α,3β)-2,3-bis(hydroxymethyl)-1-cyclobutyl>guanine (126062-18-8,126373-87-3,127759-89-1,129261-93-4,130464-69-6,130466-27-2,132077-79-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / pyridine / 16 h / 60 °C

2: 40 percent / K₂CO₃ / 18-crown-6 / dimethylformamide / 16 h / 110 °C

3: 2.) aq. HCl / 1.) sodium methoxide / 1.) methanol, 40 deg C, 1.5 h.; 2.) methanol, 50 deg C, 6 h.

With hydrogenchloride; potassium carbonate; 18-crown-6 ether; sodium methylate; In pyridine; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)88992-9

upstream raw materials:

C₃₂H₂₉N₅O₅

formic acid

(1β,2α,3β)-2,3-bis(tert-butyldimethylsiloxymethyl)cyclobutylamine

2-amino-6-chloro-5-nitro-3H-pyrimidine-4-one