N-(2-Methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

Base Information

• Chemical Name: N-(2-Methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine
• CAS No.: 1202805-24-0
• Molecular Formula: C13H22BN3O3
• Molecular Weight: 279.147
• Hs Code.: 2934999090
• Mol file: 1202805-24-0.mol

Synonyms:2-(2-Methoxyethylamino)pyrimidine-5-boronic acid, pinacol ester;N-(2-Methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

Chemical Property of N-(2-Methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

Chemical Property:

• Boiling Point: 416.1±51.0 °C(Predicted)
• PKA: 3.45±0.10(Predicted)
• PSA: 65.50000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 0.90710
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Methoxyethylamino)pyrimidine-5-boronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-Methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

There total 2 articles about N-(2-Methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-bromo-N-(2-methoxyethyl)pyrimidin-2-amine (886365-79-3) + bis(pinacol)diborane (73183-34-3) → N-(2-methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (1202805-24-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 90 ℃; Inert atmosphere;

Reference yield: 82.0%

→ N-(2-methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (1202805-24-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 105 ℃; for 17h; Inert atmosphere;

Reference yield: 68.0%

N-(2-methoxyethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (1202805-24-0) + N-(3-((7-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)oxy)phenyl)acrylamide → N-(3-((7-(2-((2-methoxyethyl)amino)pyrimidin-5-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)oxy)phenyl)acrylamide

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; Inert atmosphere;

upstream raw materials:

5-bromo-N-(2-methoxyethyl)pyrimidin-2-amine

bis(pinacol)diborane

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