(2-Thiophen-3-YL-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(2-Thiophen-3-YL-ethyl)-carbamic acid tert-butyl ester
CAS No.:179061-06-4
Molecular Formula:C₁₁H₁₇NO₂S
Molecular Weight:227.327
Hs Code.:
DSSTox Substance ID:DTXSID00598957
Wikidata:Q82494777
Mol file:179061-06-4.mol

Synonyms:179061-06-4;(2-THIOPHEN-3-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-butyl N-(2-thiophen-3-ylethyl)carbamate;tert-butyl (2-(thiophen-3-yl)ethyl)carbamate;tert-Butyl [2-(thiophen-3-yl)ethyl]carbamate;SCHEMBL8440801;DTXSID00598957;XYCUWSXIQZTIDD-UHFFFAOYSA-N;AKOS013099805;tert-butyl[2-(3-thienyl)ethyl]carbamate;tert-butyl [2-(3-thienyl)ethyl]carbamate;DB-096885;N-tert-butoxycarbonyl-2-(3-thienyl)ethylamine

Suppliers and Price of (2-Thiophen-3-YL-ethyl)-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2-THIOPHEN-3-YL-ETHYL)CARBAMIC ACID TERT-BUTYL ESTER 95.00%
5MG
$ 498.87

Total 1 raw suppliers

Chemical Property of (2-Thiophen-3-YL-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

PSA：70.06000
LogP:3.01970
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:227.09799996
Heavy Atom Count:15
Complexity:213

Purity/Quality:: (2-THIOPHEN-3-YL-ETHYL)CARBAMIC ACID TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCCC1=CSC=C1

Technology Process of (2-Thiophen-3-YL-ethyl)-carbamic acid tert-butyl ester

There total 1 articles about (2-Thiophen-3-YL-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.3%

: 24424-99-5
di-tert-butyl dicarbonate

: 34843-84-0
2-(thiophen-3-yl)ethan-1-amine hydrochloride

: 179061-06-4
N-tert-butoxycarbonyl-2-(3-thienyl)ethylamine

Guidance literature:: With potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 6h;
DOI:10.1021/jm4016284

Reference yield: 76.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 179061-06-4
N-tert-butoxycarbonyl-2-(3-thienyl)ethylamine

: 165947-52-4
6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-6H-thieno[2,3-c]pyridine

Guidance literature:: With p-toluenesulfonic acid monohydrate; In toluene; for 2h; Reflux;
DOI:10.1021/jm4016284

Reference yield:

: 179061-06-4
N-tert-butoxycarbonyl-2-(3-thienyl)ethylamine

: 1575610-02-4
(2R, 3R)-3-(2-bromo-4, 5-dihydrothieno[2, 3-c]pyridin-6(7H)-yl)-2-(2, 4-difluorophenyl)-1-(1H-1, 2, 4-triazol-1-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: p-toluenesulfonic acid monohydrate / toluene / 2 h / Reflux

2: bromine / chloroform / 12 h / 20 °C / Inert atmosphere

3: lithium perchlorate / acetonitrile / 24 h / 80 °C

With p-toluenesulfonic acid monohydrate; bromine; lithium perchlorate; In chloroform; toluene; acetonitrile;
DOI:10.1021/jm4016284