34843-84-0

Basic information

• Product Name: 3-AMINOETHYLTHIOPHENE HCL
• Synonyms: 3-AMINOETHYLTHIOPHENE HCL;3-aminoethylthiophene hydrochloride;2-Thiophen-3-yl-ethylamine hydrochloride;2-(3-Thienyl)ethanamine hydrochloride;2-(Thien-3-yl)ethylamine hydrochloride;3-Thiopheneethanamine hydrochloride;3-(2-Aminoethyl)thiophene hydrochloride;2-(thiophen-3-yl)ethan-1-aMine hydrochloride
• CAS NO: 34843-84-0
• Molecular Formula: C₆H₉NS*ClH
• Molecular Weight: 163.67
• Mol File: 34843-84-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 215-216℃
• Boiling Point: 243.7 °C at 760 mmHg
• Flash Point: 101.2 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-AMINOETHYLTHIOPHENE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINOETHYLTHIOPHENE HCL(34843-84-0)
• EPA Substance Registry System: 3-AMINOETHYLTHIOPHENE HCL(34843-84-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 34843-84-0(Hazardous Substances Data)

Usage

General Description

3-Aminoethylthiophene hydrochloride, also known as AET HCl, is a compound with the molecular formula C6H10ClNS. It is a derivative of thiophene and is commonly used in organic synthesis and pharmaceutical research. AET HCl is a versatile building block in the synthesis of various drugs, agrochemicals, and materials due to its functional amine group and thiophene ring. It has been studied for its potential use in the treatment of various diseases and disorders, and its unique properties make it a valuable tool in chemical and pharmaceutical research.

InChI:InChI=1/C6H9NS.ClH/c1-5(7)6-2-3-8-4-6;/h2-5H,7H2,1H3;1H

Upstream product

• 59311-67-0 2-(3-thienyl)ethylamine 
• 13781-53-8 (thiophen-3-yl)acetonitrile 

Downstream Products

• 893421-71-1 2-(2-bromothiophen-3-yl)ethylamine 
• 28783-50-8 3,4-dihydrothieno<2,3-c>pyridine 
• 14470-51-0 5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one 
• 960289-03-6 2-bromo-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 960289-08-1 2-(4-methoxy-phenyl)-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one 
• 179061-06-4 N-tert-butoxycarbonyl-2-(3-thienyl)ethylamine 
• 106860-33-7 2-chloro-6,7-dihydro-4H-pyrimido<6,1-a>thieno<2,3-c>pyridin-4-one 
• 106860-32-6 1-<2-(3-Thienyl)ethyl>pyrimidin-2,4,6(1H,3H,5H)trion 

Relevant articles and documents

Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia

Ulotaront (SEP-363856) is a trace-amine associated receptor 1 (TAAR1) agonist with 5-HT1A receptor agonist activity in Phase 3 clinical development, with FDA Breakthrough Therapy Designation, for the treatment of schizophrenia. TAAR1 is a G-protein-coupled receptor (GPCR) that is expressed in cortical, limbic, and midbrain monoaminergic regions. It is activated by endogenous trace amines, and is believed to play an important role in modulating dopaminergic, serotonergic, and glutamatergic circuitry. TAAR1 agonism data are reported herein for ulotaront and its analogues in comparison to endogenous TAAR1 agonists. In addition, a human TAAR1 homology model was built around ulotaront to identify key interactions and attempt to better understand the scaffold-specific TAAR1 agonism structure-activity relationships.

Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility

Triazoles with fused-heterocycle nuclei were designed and evaluated for their in vitro activity on the basis of the binding mode of albaconazole using molecular docking, along with SAR of antifungal triazoles. Tetrahydro-[1,2,4] triazolo[1,5-a]pyrazine and tetrahydro-thiazolo[5,4-c]pyridine nuclei were preferable to the other four fused-heterocycle nuclei investigated. Potent in vitro activity, broad spectrum and better water solubility were attained when triazoles containing nitrogen aromatic heterocycles were attached to these two nuclei. The most potent compounds 27aa and 45x, with low hERG inhibition and hepatocyte toxicity, both exhibited excellent activity against Candida, Cryptococcus, and Aspergillus spp., as well as selected fluconazole-resistant strains. A high water-soluble compound 58 (the disulfate salt of 45x) displayed unsatisfactory in vivo activity because of its poor PK profiles. Mice infected with C.alb. SC5314 and C.alb. 103 (fluconazole-resistant strain) and administered with 27aa displayed significantly improved survival rates. 27aa also showed favorable pharmacokinetic (PK) profiles.

NOVEL MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.