(2-METHYL-3-NITRO-PHENYL)-ACETYL CHLORIDE

Base Information

• Chemical Name: (2-METHYL-3-NITRO-PHENYL)-ACETYL CHLORIDE
• CAS No.: 101566-00-1
• Molecular Formula: C9H8ClNO3
• Molecular Weight: 213.62
• Hs Code.: 2916399090
• Mol file: 101566-00-1.mol

Synonyms:(2-METHYL-3-NITRO-PHENYL)-ACETYL CHLORIDE;2-(2-methyl-3-nitrophenyl)acetyl chloride

Chemical Property of (2-METHYL-3-NITRO-PHENYL)-ACETYL CHLORIDE

Chemical Property:

• PSA: 62.89000
• LogP: 2.73430

Purity/Quality:

(2-Methyl-3-nitrophenyl)acetyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-METHYL-3-NITRO-PHENYL)-ACETYL CHLORIDE

There total 5 articles about (2-METHYL-3-NITRO-PHENYL)-ACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(3-nitro-2-methylphenyl)acetic acid (23876-15-5) → 2-methyl-3-nitrophenylethanoyl chloride (101566-00-1)

Guidance literature:

With thionyl chloride; for 3h; Heating;

DOI:10.1016/0223-5234(96)88317-6

Reference yield:

2-methyl-3-nitrobenzic acid (1975-50-4) → 2-methyl-3-nitrophenylethanoyl chloride (101566-00-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / BH₃ / tetrahydrofuran

2: 100 percent / SOCl₂, pyridine

3: 99 percent / ethanol; H₂O

4: 97 percent / H₂SO₄, HOAc / H₂O

5: SOCl₂

With pyridine; thionyl chloride; sulfuric acid; borane; acetic acid; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm00148a028

Reference yield:

(2-methyl-3-nitrophenyl)methanol (23876-13-3) → 2-methyl-3-nitrophenylethanoyl chloride (101566-00-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / SOCl₂, pyridine

2: 99 percent / ethanol; H₂O

3: 97 percent / H₂SO₄, HOAc / H₂O

4: SOCl₂

With pyridine; thionyl chloride; sulfuric acid; acetic acid; In ethanol; water;

DOI:10.1021/jm00148a028

upstream raw materials:

2-(3-nitro-2-methylphenyl)acetic acid

2-methyl-3-nitrobenzic acid

(2-methyl-3-nitrophenyl)methanol

3-nitro-2-methylphenylacetonitrile

Downstream raw materials:

2-(2-methyl-3-nitro-phenyl)-N,N-di-n-propylacetamide

E conformation of N-benzyl,N-n-propyl (2-methyl-3-nitrophenyl)acetamide

<2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>acetic acid hydrochloride

<2-nitro-6-<2-(N,N-di-n-propylamino)ethyl>phenyl>pyruvic acid

Refernces

• 1、 Matera, Carlo,Quadri, Marta,Pelucchi, Silvia,De Amici, Marco,Dallanoce, Clelia. "A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors". . p. 1139 - 1144. Retrieved 2014/06/24.
• 2、 DeMarinis, Robert M.,Gallagher, Gregory,Hall, Ralph F.,Franz, Robert G.,Webster, Charles,et al.. "Syntheses and in Vitro Evaluation of 4-(2-Aminoethyl)-2(3H)-indolones and Related Compounds as Peripheral Prejunctional Dopamine Receptor Agonists". . p. 939 - 947. Retrieved 2007/10/02.