23876-15-5

Basic information

• Product Name: 2-Methyl-3-nitro-benzeneacetic acid
• Synonyms: 2-METHYL-3-NITRO-BENZENEACETIC ACID;(3-NITRO-O-TOLYL)ACETIC ACID;2-METHYL-3-NITROPHENYL ACETIC ACID (R4);2-Methyl-3-nitrohenylacetic acid;Ropinirole Intermediate 1;(2-Methyl-3-nitro-phenyl)-acetic acid 98% ;2-(2-methyl-3-nitrophenyl)acetic acid;2-Methyl-3-nitrophenylacetic acid 99+%
• CAS NO: 23876-15-5
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.17
• Product Categories: Pharmaceutical material and intermeidates;Aromatic Phenylacetic Acids and Derivatives;Medicine intermediate;Organic acids;Miscellaneous
• Mol File: 23876-15-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 133-135°C
• Boiling Point: 377.643 °C at 760 mmHg
• Flash Point: 168.053 °C
• Appearance: /Solid
• Density: 1.346 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 4.05±0.10(Predicted)
• CAS DataBase Reference: 2-Methyl-3-nitro-benzeneacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-3-nitro-benzeneacetic acid(23876-15-5)
• EPA Substance Registry System: 2-Methyl-3-nitro-benzeneacetic acid(23876-15-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• Hazardous Substances Data: 23876-15-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C9H9NO4/c1-6-7(5-9(11)12)3-2-4-8(6)10(13)14/h2-4H,5H2,1H3,(H,11,12)

Upstream product

• 23876-14-4 3-nitro-2-methylphenylacetonitrile 
• 83-42-1 6-chloro-2-nitrotoluene 
• 105-36-2 ethyl bromoacetate 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 623-48-3 ethyl iodoacetae 
• 41252-98-6 2-iodo-6-nitrotoluene 
• 23876-11-1 2-methyl-3-nitrobenzol-1-methandiol diacetate 
• 23876-12-2 3-formyl-2-methyl-1-nitrobenzene 
• 83-41-0 2,3-dimethylnitrobenzene 
• 60468-54-4 1-chloromethyl-2-methyl-3-nitro-benzene 
• 23876-13-3 (2-methyl-3-nitrophenyl)methanol 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 23876-17-7 ethyl 2-(2-methyl-3-nitrophenyl)acetate 

Downstream Products

• 23876-07-5 (3-amino-2-methylphenyl)acetic acid 
• 1415051-44-3 N-benzyl-2-(3-nitro-2-methylphenyl)acetamide 
• 120427-93-2 4-ethylenyl-1,3-dihydro-2H-indol-2-one 
• 120427-96-5 4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one 
• 139122-20-6 2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate 
• 23876-17-7 ethyl 2-(2-methyl-3-nitrophenyl)acetate 
• 1616596-23-6 [2-methyl-3-(1H-tetrazol-1-yl)phenyl]acetic acid 

Relevant articles and documents

Synthesis method of ropinirole hydrochloride intermediate of 2-methyl-3-nitrophenylacetic acid

The invention discloses a synthesis method of a ropinirole hydrochloride intermediate of 2-methyl-3-nitrophenylacetic acid. 6-halogenated-2-methyl nitrobenzene and halogenated ethyl acetate react under the catalyst effect to obtain 2-methyl-3-nitrophenyla

New indazole and indolone derivatives and their use pharmaceuticals

The present invention provides for compounds of formula (I), which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

4--2(3H)-indolone: A Prejunctional Dopamine Receptor Agonist

4--2(3H)-indolone (1c) (SK and F 101468) is a potent and selective prejunctional dopamine receptor agonist.It caused a dose-related inhibition of the constrictor response to electrical stimulation in the isolated perfused rabbit ear artery (EC50 = 100 nM), and this response was antagonized by (S)-sulpiride (KB = 7 nM).Compound 1c did not stimulate or block dopamine-sensitive adenylate cyclase and did not produce stimulation of the central nervous system in rats.It was prepared from (2-methyl-3-nitrophenyl)acetic acid in a multistep sequence based on the Reissert indole synthesis.