Benzeneacetonitrile, alpha-hydroxy-4-(1-methylethyl)-, (alphaS)- (9CI)

Base Information

Chemical Name:Benzeneacetonitrile, alpha-hydroxy-4-(1-methylethyl)-, (alphaS)- (9CI)
CAS No.:178357-23-8
Molecular Formula:C₁₁H₁₃NO
Molecular Weight:175.23
Hs Code.:
Mol file:178357-23-8.mol

Synonyms:Benzeneacetonitrile, alpha-hydroxy-4-(1-methylethyl)-, (alphaS)- (9CI)

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Chemical Property of Benzeneacetonitrile, alpha-hydroxy-4-(1-methylethyl)-, (alphaS)- (9CI)

Chemical Property:

Purity/Quality:

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Technology Process of Benzeneacetonitrile, alpha-hydroxy-4-(1-methylethyl)-, (alphaS)- (9CI)

There total 12 articles about Benzeneacetonitrile, alpha-hydroxy-4-(1-methylethyl)-, (alphaS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-03-2
(4-isopropylbenzaldehyde)

: 91132-18-2,178357-23-8
2-hydroxy-2-(4-isopropylphenyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: ZnI₂

2: aq. HCl / tetrahydrofuran

With hydrogenchloride; zinc(II) iodide; In tetrahydrofuran;
DOI:10.1039/C39890001391

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 122-03-2
(4-isopropylbenzaldehyde)

: 178357-23-8
(-)-4-isopropyl-α-hydroxyphenylacetonitrile

: 121985-97-5,178357-23-8
4-isopropyl-α-hydroxyphenylacetonitrile

Guidance literature:: trimethylsilyl cyanide; (4-isopropylbenzaldehyde); With titanium(IV) isopropylate; (1R,2R)-1,2-bis(3,5-di-t-pentylsalicylideneamino)cyclohexane; In dichloromethane; at -78 - 20 ℃; for 18h;

With hydrogenchloride; In dichloromethane; water; at 20 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/jo0161779

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 122-03-2
(4-isopropylbenzaldehyde)

: 178357-23-8
(-)-4-isopropyl-α-hydroxyphenylacetonitrile

: 121985-97-5,178357-23-8
4-isopropyl-α-hydroxyphenylacetonitrile

Guidance literature:: trimethylsilyl cyanide; (4-isopropylbenzaldehyde); With titanium(IV) isopropylate; (1R,2R)-1,2-bis(3,5-di-t-pentylsalicylideneamino)cyclohexane; In dichloromethane; at -78 - 20 ℃; for 18h;

With hydrogenchloride; In dichloromethane; water; at 20 ℃; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/jo0161779