2,4-Dichloro-3-methylquinoline

Base Information

• Chemical Name: 2,4-Dichloro-3-methylquinoline
• CAS No.: 56857-97-7
• Molecular Formula: C10H7Cl2N
• Molecular Weight: 212.078
• European Community (EC) Number: 889-547-1
• DSSTox Substance ID: DTXSID40355864
• Wikidata: Q82134927
• Mol file: 56857-97-7.mol

Synonyms:2,4-dichloro-3-methylquinoline;56857-97-7;Quinoline, 2,4-dichloro-3-methyl-;SCHEMBL2712314;DTXSID40355864;NVZMNNRRENJIRV-UHFFFAOYSA-N;MFCD00209479;SB71792;BS-29038;CS-0210210;FT-0610004;EN300-205195;AE-406/41055959

Chemical Property of 2,4-Dichloro-3-methylquinoline

Chemical Property:

• Vapor Pressure: 0.00154mmHg at 25°C
• Refractive Index: 1.643
• Boiling Point: 304.8 °C at 760 mmHg
• Flash Point: 166.7 °C
• PSA: 12.89000
• Density: 1.351 g/cm³
• LogP: 3.85000
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 210.9955546
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

98%Min ^*data from raw suppliers

2,4-Dichloro-3-methylquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C2=CC=CC=C2N=C1Cl)Cl

Technology Process of 2,4-Dichloro-3-methylquinoline

There total 4 articles about 2,4-Dichloro-3-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Dihydroxy-3-methyl-chinolin (1873-59-2) → 2,4-dichloro-3-methyl-quinoline (56857-97-7)

Guidance literature:

With trichlorophosphate; at 125 ℃;

Reference yield:

→ 2,4-dichloro-3-methyl-quinoline (56857-97-7)

Guidance literature:

With phosphorus pentachloride;

Reference yield:

aniline (62-53-3) → 2,4-dichloro-3-methyl-quinoline (56857-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 340 °C

2: phosphoryl chloride / 125 °C

With trichlorophosphate;

upstream raw materials:

2,4-Dihydroxy-3-methyl-chinolin

aniline

Downstream raw materials:

(4-chloro-3-methyl-[2]quinolyl)-(4-chloro-phenyl)-amine

Refernces