2-hydroxy-3-methyl-4-quinolone

Base Information

• Chemical Name: 2-hydroxy-3-methyl-4-quinolone
• CAS No.: 1873-59-2
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Hs Code.: 2933790090
• Mol file: 1873-59-2.mol

Synonyms:Carbostyril, 4-hydroxy-3-methyl- (7CI,8CI);NSC 193538;

Chemical Property of 2-hydroxy-3-methyl-4-quinolone

Chemical Property:

• Vapor Pressure: 0.000281mmHg at 25°C
• Refractive Index: 1.625
• Boiling Point: 309.153 °C at 760 mmHg
• Flash Point: 140.771 °C
• PSA: 53.09000
• Density: 1.297 g/cm³
• LogP: 1.54210
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-3-methylquinolin-2(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-hydroxy-3-methyl-4-quinolone

There total 21 articles about 2-hydroxy-3-methyl-4-quinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-methyl-3-oxo-3-(phenylamino)propanoic acid (15601-92-0) → 4-hydroxy-3-methyl-2-quinolone (1873-59-2)

Guidance literature:

With Eaton’s reagent; at 80 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/ol400587a

Reference yield: 77.0%

aniline (62-53-3) + Diethyl methylmalonate (609-08-5) → 4-hydroxy-3-methyl-2-quinolone (1873-59-2)

Guidance literature:

at 220 - 270 ℃;

DOI:10.1016/j.tet.2013.10.092

Reference yield: 75.0%

ethyl 2-(N-phenylcarbamoyl)propanoate (52629-26-2) → 4-hydroxy-3-methyl-2-quinolone (1873-59-2)

Guidance literature:

With aluminum (III) chloride; Eaton′s reagent; at 90 ℃; for 6h; Reagent/catalyst; Mechanism; Inert atmosphere;

upstream raw materials:

2-methyl-3-(2-nitro-phenyl)-3-oxo-propionic acid ethyl ester

aniline

Diethyl methylmalonate

methyl 2-(propionylamino)benzoate

Downstream raw materials:

flindersine

2-[(2-oxopropanoyl)amino]benzoic acid