(R)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
CAS No.:155251-72-2
Molecular Formula:C13H20N2O4S
Molecular Weight:300.3739
Hs Code.:
Mol file:155251-72-2.mol

Synonyms:(R)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

Suppliers and Price of (R)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Boc-(R)?-2-?(3-?Thiazolidinylcarbony?l)?pyrrolidine
500mg
$ 715.00

Total 3 raw suppliers

Chemical Property of (R)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

Chemical Property:

PSA：75.15000
LogP:1.79460
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-(R)?-2-?(3-?Thiazolidinylcarbony?l)?pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-Boc-(R)?-2-?(3-?Thiazolidinylcarbony?l)?-1-?pyrrolidine, is an impurity of Teneligliptin (T018300), is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.

Technology Process of (R)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

There total 2 articles about (R)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 155251-72-2
(R)-2-(Thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 1 h / 0 - 5 °C

2: Et₃N / CHCl₃ / 3 h / Ambient temperature

With triethylamine; In chloroform;
DOI:10.1248/cpb.41.1583

Reference yield:

: 504-78-9
1,3-thiazolidine

: C₁₅H₂₅NO₅

: 155251-72-2
(R)-2-(Thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In chloroform; for 3h; Yield given; Ambient temperature;
DOI:10.1248/cpb.41.1583

Reference yield:

: 155251-72-2
(R)-2-(Thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 4-Phenyl-1-[(R)-2-(thiazolidine-3-carbonyl)-pyrrolidin-1-yl]-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 4 N HCl / dioxane / 2 h / 60 °C

2: Et₃N / CHCl₃ / 3 h / Ambient temperature

With hydrogenchloride; triethylamine; In 1,4-dioxane; chloroform;
DOI:10.1248/cpb.41.1583