2-(4-Bromo-3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-(4-Bromo-3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 942069-45-6
• Molecular Formula: C₁₂H₁₄BBrCl₂O₂
• Molecular Weight: 351.863
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID30700046
• Wikidata: Q82631217
• Mol file: 942069-45-6.mol

Synonyms:2-(4-BROMO-3,5-DICHLOROPHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE;942069-45-6;SCHEMBL14956695;DTXSID30700046;UKPPGPXWYPWLLX-UHFFFAOYSA-N;MFCD12405328;AKOS015908160;BS-24833;CS-0153873;FT-0764793;C91268;A859532;2-(3,5-dichloro-4-(bromo)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-(4-Bromo-3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

• PSA: 18.46000
• LogP: 4.05510
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 349.96473
• Heavy Atom Count: 18
• Complexity: 299

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Bromo-3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(C(=C2)Cl)Br)Cl

Technology Process of 2-(4-Bromo-3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 2 articles about 2-(4-Bromo-3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-bromo-2,6-dichlorobenzene (19393-92-1) + bis(pinacol)diborane (73183-34-3) → 2-(4-bromo-3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (942069-45-6)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 2-(((2,6-diisopropylphenyl)imino)methyl)pyridine; In n-heptane; for 18h; Reflux;

Reference yield:

1-bromo-2,6-dichlorobenzene (19393-92-1) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-(4-bromo-3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (942069-45-6)

Guidance literature:

With (η⁵-indenyl)(η⁴-1,5-cyclooctadiene)iridium(I); 1,2-bis(dimethylphosphanyl)ethane; In cyclohexane; at 150 ℃; for 3.5h;

DOI:10.1021/ja0349857

Reference yield:

2-(4-bromo-3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (942069-45-6) → 5-(2,6-dichloro-4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile

Guidance literature:

Multi-step reaction with 2 steps

1: oxone / water; acetone / 20 °C

2: palladium diacetate; catacxium A; cesium fluoride / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere; Sealed tube

With oxone; palladium diacetate; cesium fluoride; catacxium A; In 1,4-dioxane; water; acetone; 2: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.7b00373

upstream raw materials:

1-bromo-2,6-dichlorobenzene

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

bis(pinacol)diborane

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