6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 26218-75-7
• Molecular Formula: C7H6BrNO2
• Molecular Weight: 216.034
• Hs Code.: 29333990
• Mol file: 26218-75-7.mol

Synonyms:Picolinicacid, 6-bromo-, methyl ester (8CI);6-Bromopyridine-2-carboxylic acid methylester;Methyl 2-bromopyridine-6-carboxylate;Methyl 6-bromopicolinate;

Chemical Property of 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 92-96°C(lit.)
• Refractive Index: 1.554
• Boiling Point: 289.739 °C at 760 mmHg
• PKA: -1.03±0.10(Predicted)
• Flash Point: 129.03 °C
• PSA: 39.19000
• Density: 1.58 g/cm³
• LogP: 1.63070
• Storage Temp.: Keep Cold
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

Methyl 6-bromopicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

There total 8 articles about 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 6-bromo-pyridine-2-carboxylic acid (21190-87-4) → methyl 6-Bromopicolinate (26218-75-7)

Guidance literature:

methanol; 6-bromo-pyridine-2-carboxylic acid; sulfuric acid; for 4h; Heating / reflux;

With ammonia; In water; at 0 ℃;

Reference yield: 98.0%

methanol (67-56-1) + 6-bromo-2-pyridinecarbaldehyde (34160-40-2) → methyl 6-Bromopicolinate (26218-75-7)

Guidance literature:

With water; iodine; sodium nitrite; at 20 - 70 ℃; chemoselective reaction;

DOI:10.1055/s-0029-1217121

Reference yield: 97.0%

6-bromo-pyridine-2-carboxylic acid (21190-87-4) + methyl iodide (74-88-4) → methyl 6-Bromopicolinate (26218-75-7)

Guidance literature:

With potassium carbonate;

upstream raw materials:

diazomethane

6-bromo-pyridine-2-carboxylic acid

methyl iodide

methanol

Downstream raw materials:

6-[2-(3,4,5-trimethoxy-phenylamino)-pyrrolo[2,3-d]pyrimidin-7-yl]-pyridine-2-carboxylic acid methyl ester

C₃₀H₃₄N₂O₃

C₁₃H₁₀ClNO₂

6-(4-Trifluoromethoxy-phenyl)-pyridine-2-carboxylic acid methyl ester

Refernces

• 1、 Dechert, Sebastian,Demeshko, Serhiy,Hua, Shao-An,Meyer, Franc,Wong, Joanne W. L.,Ye, Shengfa. "Bis(pyrazolato) Bridged Diiron Complexes: Ferromagnetic Coupling in a Mixed-Valent HS-FeII/LS-FeIII Dinuclear Complex". . p. 4137 - 4145. Retrieved 2020.
• 2、 -. "ASK1 ISOINDOLIN-1-ONE INHIBITORS AND METHODS OF USE THEREOF". Paragraph 0319-0320. . Retrieved 2020/01/22.