AZD8186

Base Information

• Chemical Name: AZD8186
• CAS No.: 1627494-13-6
• Molecular Formula: C24H25F2N3O4
• Molecular Weight: 457.47
• Mol file: 1627494-13-6.mol

Synonyms:AZD8186;AZD 8186, >=98%;(R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide;8-[(1R)-1-[(3,5-Difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-6-carboxamide

Chemical Property of AZD8186

Chemical Property:

• Boiling Point: 645.2±55.0 °C(Predicted)
• PKA: 2.56±0.50(Predicted)
• PSA: 75.02000
• Density: 1.351±0.06 g/cm3(Predicted)
• LogP: 3.92070
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

AZD8186 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: AZD 8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ for the treatment of PTEN-deficient cancers.

Technology Process of AZD8186

There total 99 articles about AZD8186 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.5%

8-(1-bromoethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (1296271-50-5) + 3,5-difluoroaniline (372-39-4) → 8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (1296271-95-8,1296271-96-9,1296270-45-5,1627494-13-6)

Guidance literature:

In N,N-dimethyl-formamide; at 50 ℃; for 5h; Inert atmosphere;

Reference yield:

8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (1296271-95-8,1296271-96-9,1296270-45-5,1627494-13-6) → 8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (1627494-13-6) + (-)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (1627494-13-6)

Guidance literature:

With Chiralpak IC; In methanol; diethylamine; acetonitrile; at 20 ℃; for 0.833333h; Resolution of racemate;

Reference yield:

8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (1296271-95-8,1296271-96-9,1296270-45-5,1627494-13-6) → 8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (1627494-13-6) + (-)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (1627494-13-6)

Guidance literature:

With Chiralpak IC; In methanol; diethylamine; acetonitrile; at 20 ℃; for 0.833333h; Resolution of racemate;

upstream raw materials:

8-(1-bromoethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

3,5-difluoroaniline

methyl 8-acetyl-2-morpholino-4-oxo-4H-chromene-6-carboxylate

8-(1-hydroxyethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1627494-13-6 AZD8186

Send

Send

Metric Ton KG G Pound L ML

Send

Send