Cyclopentanecarbonitrile, 1-[(tetrahydro-2H-pyran-2-yl)oxy]- (9CI)

Base Information

• Chemical Name: Cyclopentanecarbonitrile, 1-[(tetrahydro-2H-pyran-2-yl)oxy]- (9CI)
• CAS No.: 37802-93-0
• Molecular Formula: C11H17NO2
• Molecular Weight: 195.25818
• Hs Code.: 2932999099
• Mol file: 37802-93-0.mol

Synonyms:Cyclopentanecarbonitrile, 1-[(tetrahydro-2H-pyran-2-yl)oxy]- (9CI)

Chemical Property of Cyclopentanecarbonitrile, 1-[(tetrahydro-2H-pyran-2-yl)oxy]- (9CI)

Chemical Property:

• Boiling Point: 130-132 °C(Press: 14 Torr)
• PSA: 42.25000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 2.36598

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarbonitrile, 1-[(tetrahydro-2H-pyran-2-yl)oxy]- (9CI)

There total 2 articles about Cyclopentanecarbonitrile, 1-[(tetrahydro-2H-pyran-2-yl)oxy]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-acetoxytetrahydropyran (2761-33-3) + trimethylsilyl cyanide (7677-24-9) + cyclopentanone (120-92-3) → 1-tetrahydropyran-2-yloxy-cyclopentanecarbonitrile (37802-93-0)

Guidance literature:

trimethylsilyl cyanide; cyclopentanone; iron(III) trifluoromethanesulfonate; In various solvent(s); at 0 ℃; for 0.5h;

2-acetoxytetrahydropyran; In various solvent(s); at -78 ℃; for 3h;

DOI:10.1016/j.tetlet.2006.04.106

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + 1-hydroxycyclopentanecarbonitrile (5117-85-1) → 1-tetrahydropyran-2-yloxy-cyclopentanecarbonitrile (37802-93-0)

Guidance literature:

With hydrogenchloride; diethyl ether;

Reference yield:

1-tetrahydropyran-2-yloxy-cyclopentanecarbonitrile (37802-93-0) → 1-acetylcyclopentanol (17160-89-3)

Guidance literature:

With diethyl ether; methylmagnesium bromide; anschliessendes Behandeln mit wss.NH₄Cl und Erwaermen des Reaktionsprodukts in Aether mit wss.HCl;

upstream raw materials:

3,4-dihydro-2H-pyran

1-hydroxycyclopentanecarbonitrile

2-acetoxytetrahydropyran

trimethylsilyl cyanide

Downstream raw materials:

1-[amino(phenyl)methyl]cyclopentanol

1-acetylcyclopentanol

(1-hydroxycyclopentyl)(m-tolyl)methanone

(1-hydroxycyclopentyl)(p-tolyl)methanone