5-cyclopropylpicolinic acid

Base Information

• Chemical Name: 5-cyclopropylpicolinic acid
• CAS No.: 1174322-66-7
• Molecular Formula: C9H9NO2
• Molecular Weight: 163.176
• Hs Code.: 2933399090
• Mol file: 1174322-66-7.mol

Synonyms:5-cyclopropylpicolinic acid

Chemical Property of 5-cyclopropylpicolinic acid

Chemical Property:

• PSA: 50.19000
• LogP: 1.65720
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-CyclopropylpicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-cyclopropylpicolinic acid

There total 7 articles about 5-cyclopropylpicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-bromopicolinate (29682-15-3) → 5-cyclopropylpicolinic acid (1174322-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / 80 °C / Sealed tube; Inert atmosphere

2.1: potassium hydroxide / methanol / 1 h / 50 °C

2.2: pH 2

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

tert-butyl 5-cyclopropyl-pyridine-2-carboxylate (1174322-67-8) → 5-cyclopropylpicolinic acid (1174322-66-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.33h;

Reference yield:

methyl 5-cyclopropylpicolinate (1415898-72-4) → 5-cyclopropylpicolinic acid (1174322-66-7)

Guidance literature:

methyl 5-cyclopropylpicolinate; With potassium hydroxide; In methanol; at 50 ℃; for 1h;

With hydrogenchloride; In methanol; water; pH=2;

upstream raw materials:

tert-butyl 5-cyclopropyl-pyridine-2-carboxylate

methyl 5-bromopicolinate

methyl 5-cyclopropylpicolinate

5-bromopyridine-2-carboxylic acid benzyl ester

Refernces

• 1、 -. "FUSED MULTI-CYCLIC SULFONE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF". . . Retrieved 2014/08/07.