5-bromopyridine-2-carboxylic acid benzyl ester

Base Information

• Chemical Name: 5-bromopyridine-2-carboxylic acid benzyl ester
• CAS No.: 188052-14-4
• Molecular Formula: C₁₃H₁₀BrNO₂
• Molecular Weight: 292.132
• Mol file: 188052-14-4.mol

Synonyms:5-bromopyridine-2-carboxylic acid benzyl ester

Chemical Property of 5-bromopyridine-2-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Benzyl5-bromopicolinate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromopyridine-2-carboxylic acid benzyl ester

There total 5 articles about 5-bromopyridine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

carbon monoxide (201230-82-2) + 2-iodo-5-bromopyridine (223463-13-6) + benzyl alcohol (100-51-6,185532-71-2) → 5-bromopyridine-2-carboxylic acid benzyl ester (188052-14-4)

Guidance literature:

With TEA; bis-triphenylphosphine-palladium(II) chloride; at 60 ℃; for 15h; under 3102.97 Torr;

DOI:10.1021/jo0013554

Reference yield: 52.0%

2,5-dibromopyridine (624-28-2) + carbon monoxide (201230-82-2) + benzyl alcohol (100-51-6,185532-71-2) → 5-bromopyridine-2-carboxylic acid benzyl ester (188052-14-4)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 50 ℃; under 1551.4 Torr;

DOI:10.1080/00397919708006053

Reference yield:

5-bromopyridine-2-carbonyl chloride (137178-88-2) + benzyl alcohol (100-51-6,185532-71-2) → 5-bromopyridine-2-carboxylic acid benzyl ester (188052-14-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 25 ℃; Cooling with ice;

upstream raw materials:

2,5-dibromopyridine

carbon monoxide

benzyl alcohol

2-iodo-5-bromopyridine

Downstream raw materials:

benzyl (S)-5-(3-hydroxy-but-1-ynyl)pyridine-2-carboxylate

5-isopropyl-2-pyridinecarboxylic acid

5-cyclopropylpicolinic acid

tert-butyl 4-[2-(benzyloxycarbonyl)pyridin-5-yl]-3,6-dihydro-2H-pyridine-1-carboxylate