N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)-5-Pyrimidinecarboxamide

Base Information

Chemical Name:N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)-5-Pyrimidinecarboxamide
CAS No.:1452230-52-2
Molecular Formula:C₁₃H₁₁Cl₂N₃OS
Molecular Weight:328.222
Hs Code.:
Mol file:1452230-52-2.mol

Synonyms:N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)-5-Pyrimidinecarboxamide

Suppliers and Price of N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)-5-Pyrimidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)-5-Pyrimidinecarboxamide

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)-5-Pyrimidinecarboxamide

There total 4 articles about N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)-5-Pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 98276-75-6
4-methyl-2-(methylthio)pyrimidine-5-carboxylic acid

: 608-31-1
2,6-Dichloroaniline

: 1452230-52-2
N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)pyrimidine-5-carboxamide

Guidance literature:: With phosphorus trichloride; In chlorobenzene; at 135 ℃; for 3h; Inert atmosphere;

Reference yield:

: 608-31-1
2,6-Dichloroaniline

: 4-methyl-2-methylsulfanyl-pyrimidine-5-carbonyl chloride

: 1452230-52-2
N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)pyrimidine-5-carboxamide

Guidance literature:: In 1,4-dioxane; at 100 ℃; for 16h;
DOI:10.1016/j.bmcl.2019.04.017

Reference yield:

: 7234-25-5
4-methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester

: 1452230-52-2
N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; methanol / 12 h / 20 °C

2.1: N,N-dimethyl-formamide; thionyl chloride / 1,4-dioxane / 1 h / 20 °C

2.2: 100 °C

With thionyl chloride; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol;