98276-75-6

Basic information

• Product Name: 4-METHYL-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
• Synonyms: 4-METHYL-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID;4-Methyl-2-(methylthio)pyrimidine-5-carboxylic acid ,97%;4-Methyl-2-(methylsulphanyl)pyrimidine-5-carboxylic acid;4-Methyl-2-(methylsulphanyl)pyrimidine-5-carboxylic acid, 5-Carboxy-4-methyl-2-(methylthio)pyrimidine, 5-Carboxy-4-methyl-2-(methylsulphanyl)pyrimidine;4-methyl-2-methylsulfanylpyrimidine-5-carboxylic acid;5-Pyrimidinecarboxylicacid, 4-methyl-2-(methylthio)-;4-Methyl-2-(methylsulfanyl)-5-pyrimidinecarboxylic acid≥ 98.5% (HPLC);4-Methyl-2-(methylthio)-5-pyrimidinecarboxylic Acid
• CAS NO: 98276-75-6
• Molecular Formula: C₇H₈N₂O₂S
• Molecular Weight: 184.2
• Mol File: 98276-75-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 169-171
• Boiling Point: 379.9°Cat760mmHg
• Flash Point: 183.5°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 1.9E-06mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 4-METHYL-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID(98276-75-6)
• EPA Substance Registry System: 4-METHYL-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID(98276-75-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 98276-75-6(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C7H8N2O2S/c1-4-5(6(10)11)3-8-7(9-4)12-2/h3H,1-2H3,(H,10,11)

Upstream product

• 49836-24-0 (E)-2-(ethoxymethylene)-3-oxobutanoic acid ethyl ester 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 134653-70-6 α-acetyl-α-(dimethylaminomethylene)acetic acid,ethyl ester 
• 2986-19-8 carbamimidothioic acid methyl ester 
• 122-51-0 orthoformic acid triethyl ester 
• 7234-25-5 4-methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 1452230-52-2 N-(2,6-dichlorophenyl)-4-methyl-2-(methylthio)pyrimidine-5-carboxamide 
• 1452231-32-1 N-(2-chloro-6-fluorophenyl)-4-methyl-2-(methylthio)pyrimidine-5-carboxamide 
• 66373-26-0 1-(4-methyl-2-methylsulfanylpyrimidin-5-yl)ethanone 
• 93584-03-3 5-acetyl-4-methyl-2-pyrimidinylhydrazine 
• 14001-63-9 2-methylthio-4-methylpyrimidine 
• 1452232-82-4 6-(2,6-dichlorophenyl)-8-(1-hydroxyethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452231-63-8 tert-butyl 6-(6-(2,6-dichlorophenyl)-8-formyl-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-ylamino)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1452231-33-2 6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde 
• 1452231-20-7 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452231-11-6 2-amino-6-(2,6-dichlorophenyl)-8-(1H-imidazol-2-yl)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-84-0 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-83-9 6-(2,6-dichlorophenyl)-8-(fluoromethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-82-8 6-(2,6-dichlorophenyl)-8-(hydroxymethyl)-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one 
• 1452230-81-7 6-(2,6-dichlorophenyl)-8-(fluoromethyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one 

Relevant articles and documents

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Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate: An inhibitor of AP-1 and NF-κB mediated gene expression

Several analogues of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate (1) were synthesized and tested as inhibitors of AP-1 and NF-κB mediated transcriptional activation in Jurkat T cells. From our SAR work, ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))-N-methylamino]-4-(trifluoromethyl)- pyrimidine-5-carboxylate was identified as a novel and potent inhibitor.