tert-butyl 4-(4-(pyrrolidin-1-yl)phenyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-(pyrrolidin-1-yl)phenyl)piperidine-1-carboxylate
• CAS No.: 1362205-33-1
• Molecular Formula: C₂₀H₃₀N₂O₂
• Molecular Weight: 330.47
• Mol file: 1362205-33-1.mol

Synonyms:tert-butyl 4-(4-(pyrrolidin-1-yl)phenyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(4-(pyrrolidin-1-yl)phenyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl 4-(4-(pyrrolidin-1-yl)phenyl)piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-(4-(pyrrolidin-1-yl)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

pyrrolidine (123-75-1) + tert-butyl 4-(4-bromophenyl)piperidine-1-carboxylate (769944-78-7) → tert-butyl 4-(4-(pyrrolidin-1-yl)phenyl)piperidine-1-carboxylate (1362205-33-1)

Guidance literature:

With johnphos; sodium t-butanolate; palladium diacetate; In toluene; at 90 ℃; for 3h;

Reference yield:

tert-butyl 4-(4-(pyrrolidin-1-yl)phenyl)piperidine-1-carboxylate (1362205-33-1) + trifluoroacetic acid (76-05-1) → C15H22N2*C2HF3O2

Guidance literature:

In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2019.115096

upstream raw materials:

pyrrolidine

tert-butyl 4-(4-bromophenyl)piperidine-1-carboxylate