(R)-b-AMino-4-chloro-benzeneethanol

Base Information

• Chemical Name: (R)-b-AMino-4-chloro-benzeneethanol
• CAS No.: 1067658-27-8
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Hs Code.: 2922199090
• Mol file: 1067658-27-8.mol

Synonyms:(R)-b-AMino-4-chloro-benzeneethanol;(2R)-2-AMINO-2-(4-CHLOROPHENYL)ETHAN-1-OL;(R)-2-amino-2-(4-chlorophenyl)ethan-1-ol

Chemical Property of (R)-b-AMino-4-chloro-benzeneethanol

Chemical Property:

• Boiling Point: 319.8±27.0 °C(Predicted)
• PKA: 12.43±0.10(Predicted)
• PSA: 46.25000
• Density: 1.260±0.06 g/cm3(Predicted)
• LogP: 2.03240
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-Amino-2-(4-chlorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-b-AMino-4-chloro-benzeneethanol

There total 7 articles about (R)-b-AMino-4-chloro-benzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-amino-2-(4-chlorophenyl)acetic acid (43189-37-3,7292-70-8) → (R)-2-amino-2-(4-chlorophenyl)ethanol (1067658-27-8)

Guidance literature:

(R)-2-amino-2-(4-chlorophenyl)acetic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Inert atmosphere; Reflux;

With water; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/jm401767k

Reference yield: 87.0%

(R)-2-azido-2-(4-chlorophenyl)ethan-1-ol (1268337-06-9) → (R)-2-amino-2-(4-chlorophenyl)ethanol (1067658-27-8)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 70 ℃;

DOI:10.1016/j.tetasy.2015.12.002

Reference yield: 82.0%

(R)-2-(4-chlorophenyl)glycine methyl ester hydrochloride (59410-89-8) → (R)-2-amino-2-(4-chlorophenyl)ethanol (1067658-27-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; water; at 0 ℃; Reflux; Inert atmosphere;

DOI:10.1016/j.tetasy.2013.09.009

upstream raw materials:

(R)-2-amino-2-(4-chlorophenyl)acetic acid

(R)-2-(4-chlorophenyl)glycine methyl ester hydrochloride

(2S)-2-(4-chlorophenyl)oxirane

4-chlorobenzoylmethyl bromide

Downstream raw materials:

(S)-4-tert-butyl 1-((R)-2-(4-chlorophenyl)-2-(pent-4-enamido)ethyl) 2-allylsuccinate

tert-butyl 2-((3R,11S,E)-3-(4-chlorophenyl)-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl)acetate

N-(4-chlorobenzyl)-2-((3R,11S,E)-3-(4-chlorophenyl)-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl)acetamide

(R)-N-(1-(4-chlorophenyl)-2-hydroxyethyl)pent-4-enamide