METHYL D-4-CHLOROPHENYLGLYCINATE HCL

Base Information

• Chemical Name: METHYL D-4-CHLOROPHENYLGLYCINATE HCL
• CAS No.: 59410-89-8
• Molecular Formula: C₉H₁₀ClNO₂*ClH
• Molecular Weight: 236.098
• Hs Code.: 2922499990
• Mol file: 59410-89-8.mol

Synonyms:Benzeneaceticacid, a-amino-4-chloro-, methyl ester, hydrochloride, (R)-; Benzeneacetic acid, a-amino-4-chloro-,methyl ester, hydrochloride, (aR)- (9CI)

Chemical Property of METHYL D-4-CHLOROPHENYLGLYCINATE HCL

Chemical Property:

• PSA: 38.33000
• LogP: 2.79990
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

MethylD-4-ChlorophenylglycinateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL D-4-CHLOROPHENYLGLYCINATE HCL

There total 6 articles about METHYL D-4-CHLOROPHENYLGLYCINATE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2-(4-Chlorophenyl)glycine (6212-33-5,7292-70-8) → dl-α-4-chlorophenylglycine methyl ester hydrochloride (42718-19-4,59410-89-8)

Guidance literature:

With thionyl chloride; for 3h; Heating;

DOI:10.1039/b713065a

Reference yield: 100.0%

2-(4-Chlorophenyl)glycine (6212-33-5,7292-70-8) → dl-α-4-chlorophenylglycine methyl ester hydrochloride (42718-19-4,59410-89-8)

Guidance literature:

methanol; With thionyl chloride; at 0 ℃; for 0.75h;

2-(4-Chlorophenyl)glycine; at 0 - 40 ℃; for 48h;

Reference yield: 100.0%

methanol (67-56-1) + (S)-2-amino-2-(4-chlorophenyl)acetic acid (67336-19-0,7292-70-8) → (S)-4-chlorophenylglycine methyl ester hydrochloride (1081766-09-7,59410-89-8)

Guidance literature:

With chloro-trimethyl-silane; at 0 - 20 ℃; for 24h; Inert atmosphere;

upstream raw materials:

methanol

2-(4-Chlorophenyl)glycine

4-chlorobenzaldehyde

(R)-(4-Chloro-phenyl)-((R)-2-methyl-propane-2-sulfinylamino)-acetic acid methyl ester

Downstream raw materials:

C₂₃H₂₇ClN₄O₅

ethyl [3-(4-chlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]acetate

[3-(4-chlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]acetic acid

[3-(4-chlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl]acetyl chloride

Refernces

• 1、 Teegardin, Kip A.,Gotcher, Lacey,Weaver, Jimmie D.. "Formation of Non-Natural α,α-Disubstituted Amino Esters via Catalytic Michael Addition". supporting information. p. 7239 - 7244. Retrieved 2018/11/25.
• 2、 Bon, Robin S.,Sprenkels, Nanda E.,Koningstein, Manoe M.,Schmitz, Rob F.,De Kanter, Frans J. J.,Doemling, Alexander,Groen, Marinus B.,Orru, Romano V. A.. "Efficient C2 functionalisation of 2H-2-imidazolines". . p. 130 - 137. Retrieved 2008/09/20.