Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate

Base Information

• Chemical Name: Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate
• CAS No.: 676621-95-7
• Molecular Formula: C13H17FO2
• Molecular Weight: 224.275
• Mol file: 676621-95-7.mol

Synonyms:Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate

Chemical Property of Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate

Chemical Property:

• PSA: 26.30000
• LogP: 2.95750
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-(4-fluorophenyl)-2,2-dimethylpropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate

There total 1 articles about Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Fluorobenzyl bromide (459-46-1) + Ethyl isobutyrate (97-62-1) → 3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid Ethyl Ester (676621-95-7)

Guidance literature:

Ethyl isobutyrate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

4-Fluorobenzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; for 18h;

Reference yield: 97.0%

3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid Ethyl Ester (676621-95-7) → 2,2-dimethyl-3-(4-fluoro)phenylpropanol (483368-32-7)

Guidance literature:

3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid Ethyl Ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1.5h;

With water; sodium sulfate; In tetrahydrofuran; for 0.5h;

Reference yield: 87.0%

3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid Ethyl Ester (676621-95-7) → 3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid (676621-96-8)

Guidance literature:

3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid Ethyl Ester; With sodium hydroxide; water; for 18h; Heating / reflux;

With hydrogenchloride; In water; at 0 ℃; pH=1;

upstream raw materials:

4-Fluorobenzyl bromide

Ethyl isobutyrate

Downstream raw materials:

3-(4-Fluorophenyl)-2,2-dimethyl-propionic Acid

2,2-dimethyl-3-(4-fluoro)phenylpropanol

3-(4-fluorophenyl)-2,2-dimethylpropionamide

N-methyl-2,2-dimethyl-3-(4-fluorophenyl)propylamine

Refernces

• 1、 -. "N-substituted heterocyclic amines as modulators of chemokine receptor activity". Page/Page column 29. . Retrieved 2010/02/06.